Polygenic background contributes to GCK-MODY clinical presentation and glycaemic variability - Diabetologia Aims/hypothesis GCK-MODY (glucokinase MODY) causes lifelong, mild hyperglycaemia with high penetrance. Variation in glycaemic phenotype among carriers remains unexplained. We hypothesised that polygen...

In GCK-MODY, polygenic background modifies clinical presentation despite high penetrance. Polygenic risk influences who crosses key diagnostic HbA1c thresholds. Monogenic + polygenic risk both matter. #Diabetes #Genetics #MODY #PrecisionMedicine link.springer.com/article/10.1... 🔓

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Cody & Molly have snuggle session while watching #SenseAndSensibility. 🥰 #Mody #GH

Molly: "If you want to end things between us right now, that's totally fine. Bc not having kids is a huge sacrifice."
Cody: "Maybe for some other people but not for me."
This is why Molly walked away from TJ, bc she knew how much he wanted kids that endometriosis prevented her from having
#Mody #GH

KV is so good with Molly's quiet pain at admitting the damage her endometriosis has done means she can't have children. And JK nailed Cody's quiet questions giving Molly the chance to open up about her health and their possible future. #Mody #GH

Just started the episode, and greatly looking forward to the #Mody scenes. 💞 #GH

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Cody shows up with a Feel-Better-Soon basket for Molly, but she says that he's making things even harder for her. #Mody #GH

A systematic analysis of loss-of-function variants in MODY-related genes expands our understanding of variants that cause #MODY #DiabetesResearch #Genetics

Systematic analysis of loss-of-function variants across MODY genes demonstrates gene-specific effects and expands the spectrum of INS variants causing MODY - Diabetologia Aims/hypothesis Accurate interpretation of loss-of-function (LOF) variants in MODY genes is essential for diagnosis but remains challenging, particularly for variants that are predicted to escape nons...

Systematic analysis of loss-of-function variants across MODY genes demonstrates gene-specific effects and expands the spectrum of INS variants causing MODY #MODY #Insulin #Genetics #DiabetesResearch link.springer.com/article/10.1... 🔓

Yeah, it's about time we had some movement on the #Mody front!! #GH

Molly is so nervous about Cody's confrontation over her book that she's ordering "whiskey - neat". 🤣 #Mody #GH

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Today's #GH is opening with Gio & Emma followed by Cody & Molly - already this is the strongest episode of the week!! #Gemma #Mody

Today had #Gemma, #Mody, and the start of #Elante (I agree it's a better name than Diz) #GH

#GH #Mody #Colly #JaBritt #Jackly #DanLotte #CharDan GREAT MONTAGE at the end of Jason+Britt sleeping together .. Jack and Carly sleeping together as Val is in the attic .. Cody angry as Molly is upset .. Rocco making smores as Charlotte and Danny look at each other romantically

#GH #Mody #Colly Cody and Molly had a big fight about how she presented his character in her book .. She made him look silly .. But she said the character changes .. He's still hurt and angry though ..

#Mody still talking about the book and Cody being mad and Nathan and lulu talking about Maxie in today's episode #GH

#GH #Colly #Mody I think Cody's reading a copy of Molly's book right now ...

#GH #Colly #Mody Cody had a funny line about how if Molly wasn't in law enforcement they would never have met .. Haha .. He encouraged her to pursue her writing career but she wanted to sleep with him right now tonight instead ..

#GH #Mody #Colly I'm not hearing much between Cody and Molly but she got a message a publisher may want a multi book deal form her .. Kristina sent it to the publisher I guess? .. Molly says she has a job and doesn't want to do the book tours

#GH #Colly #Mody Tuned in at .. 200 pm est .. Again today ... YAY .. Cody to Molly 'We're snowed in'

And Cody is reading Molly's #LaredoSunrise manuscript - I bet the hero feels familiar!! 🥰 #Mody #GH

I love when he picks her up and carries her! 🥰

#Mody 🥰

Molly continues to talk about her book and being happy the agent liked it but she doesn't want to give up her ADA job. Cody can't wait to read it and it looks like Molly's ready to experience parts of it with him upstairs. He carries her up #Mody #GH

#optogenetics #light #green 💚✳️🐭
#PDX1 #insulin #NEUROD1 #GSK3 #hypoglicemia #pancreaticcancer #MODY #diabetes

I also wonder if Molly and Cody are going to be trapped in the stables and have to find warmth by the fire... #Mody #GH

Fantastic talk by Dr. Aisha Ansar on monogenic diabetes. GCK-MODY causes mild, stable hyperglycemia with preserved C-peptide, negative antibodies, and low complication risk—critical to recognize when evaluating patients with atypical diabetes.
#MonogenicDiabetes #MODY @washumedicine.bsky.social

#GH #Colly #Mody #DavisGirls #TheDavisGirls Cody and Molly cleared everything up .. After she went to see him .. I guess .. They're back on the same .. Boyfriend / girlfriend track together now .. I guess

#GH #Colly #Mody #DavisGirls #TheDavisGirls Molly told Kristina she regrets not claiming to be Cody's girlfriend that way .. Kristina said 'it was a miscommunication' .. Molly said 'It's awkward' Kristina 'U just need to clean things up .. There's no time like the present'

#GH #Colly #Mody Cody to Felicia 'It's different with her .. She's smart .. I got to know her before I acted on my feelings .. I admire her .. I couldn't get her out of my head .. I still can't' Cody has it bad for Molly as they say ..

#GH #Colly #Mody #Tolly Cody and Felicia discussed Molly not saying she's Cody's girlfriend the other day .. Felicia said Molly seems happy now though .. Cody said her break up with TJ is 'fresh .. I should've realized she wouldn't want to jump into a relationship'

#Mody made things official as a couple in today's episode #GH