Scientists develop PSB‑172656, a potent small‑molecule #antagonist of mast cell receptor #MRGPRX2, with subnanomolar activity and efficacy in blocking human/mouse orthologs to prevent #AllergicReactions and #anaphylaxis. @unibonn.bsky.social

#CoverPage #STTT: doi.org/10.1038/s413...

Lactic acid suppresses MRGPRX2 mediated mast cell responses - PubMed MAS related G-protein coupled receptor X2 (MRGPRX2) is a G-protein coupled receptor (GPCR) expressed in human mast cells that has been implicated to play an important role in causing pseudo-allergic r...

pubmed.ncbi.nlm.nih.gov/34399172/

"MAS related G-protein coupled receptor X2 ( #MRGPRX2) is a G-protein coupled receptor ( #GPCR) expressed in human mast cells that has been implicated to play an important role in causing pseudo-allergic reactions"

Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models

Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models #MRGPRX2 #MCAS #MECFS #LongCovid

www.nature.com/articles/s41...

Characterisation of MRGPRX2+ mast cells in irritable bowel syndrome Background Mast cell activation is an important driver of abdominal pain in irritable bowel syndrome (IBS). While evidence supports the role of IgE-mediated mast cell activation in visceral pain devel...

Our new paper is also out in Gut! gut.bmj.com/content/earl...
#Mastcells #IBS #GISky #Immunosky #MRGPRX2 #pain

Evommune Unveils Groundbreaking Clinical Findings for EVO756 at GA²LEN Global Urticaria Forum Evommune, Inc. showcased promising clinical trial results for EVO756 targeting chronic inflammatory diseases at the GA²LEN Forum, sparking optimism in treatment advancements.

Evommune Unveils Groundbreaking Clinical Findings for EVO756 at GA²LEN Global Urticaria Forum #Germany #Berlin #Evommune #EVO756 #MRGPRX2