TRAMP assembly alters the conformation and RNA binding of Mtr4 and Trf4-Air2 | PNAS The TRAMP complex contains two enzymatic activities essential for RNA processing upstream of the nuclear exosome. Within TRAMP, RNA is 3′ polyadeny...

Nice work from Sean Johnson on "The Molecular Mechanisms of RNA Processing in the TRAMP RNA Surveillance Complex presented today at #RNASociety #Emory GA RNA Salon! @rnasociety.bsky.social #RNA #TRAMP #RNAExosome #RNADecay #Mtr4

www.pnas.org/doi/10.1073/...

The nuclear exosome co-factor MTR4 shapes the transcriptome for meiotic initiation Nature Communications - Nuclear RNA decay regulates gene expression in cultured cells, but its role in animals is largely unclear. Here, authors found that the nuclear exosome co-factor MTR4...

Cool! #MTR4 #RNADecay #RNA #RNAExosome
The #nuclear #exosome co-factor #MTR4 shapes the #transcriptome for #meiotic initiation

Li Zhang, Jianshu Wang, Zhidong Tang, Zhen Lin, Ruibao Su, Naijing Hu, Yao Tang, Gaoxiang Ge, Jing Fan, Ming-Han Tong, Yuanchao Xue, Yu Zhou & Hong Cheng
rdcu.be/ed5WM

Nuclear retention of unspliced HIV-1 RNA as a reversible post-transcriptional block in latency - Nature Communications In their study, Dorman and Bendoumou et al., reveal a post-transcriptional regulation of unspliced HIV-1 RNA by host factors MATR3, MTR4, and the viral protein Rev, identifying a previously uncharacte...

Interesting!
#HIV1 #RNA #Rev #MTR4 #MATR3
www.nature.com/articles/s41...

#TRAMP #Trf4 #Air2 #Mtr4 #RNA #RNAsky

TRAMP assembly alters the conformation and RNA binding of Mtr4 and Trf4-Air2 | PNAS www.pnas.org/doi/10.1073/...