By tuning proton transport, researchers aim for ‘mild‘ uncoupling that preserves ATP – and avoids the historical trap of overheating.

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A systems-level, semi-quantitative landscape of metabolic flux in C. elegans | Nature Metabolic flux, or the rate of metabolic reactions, is one of the most fundamental metrics describing the status of metabolism in living organisms. However, measuring fluxes across the entire metabolic network remains nearly impossible, especially in multicellular organisms. Computational methods based on flux balance analysis have been used with genome-scale metabolic network models to predict network-level flux wiring1–6. However, such approaches have limited power because of the lack of experimental constraints. Here, we introduce a strategy that infers whole-animal metabolic flux wiring from transcriptional phenotypes in the nematode Caenorhabditis elegans. Using a large-scale Worm Perturb-Seq (WPS) dataset for roughly 900 metabolic genes7, we show that the transcriptional response to metabolic gene perturbations can be integrated with the metabolic network model to infer a highly constrained, semi-quantitative flux distribution. We discover several features of adult C. elegans met

Epic breakthrough! Semi-quantitative metabolic flux map in C. elegans created. Revolutionary for systems biology! #MetabolicScience 🔬📊 PMID:40011784, Nature 2025, @Nature https://doi.org/10.1038/s41586-025-08635-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪