Thrilled to announce our new National Project funded by the Agencia Estatal de Investigación and the Ministerio de Ciencia, Innovación y Universidades, focused on #CancerResearch #Metallopeptides #DNAJunctions #ChemicalBiology #SupramolecularChemistry

This work highlights the potential of metallopeptides as therapeutic agents, leveraging Cu(II) transport and ROS modulation as key anticancer strategies.

Thanks to all my collaborators! 😊

🔗 Full article: pubs.acs.org/articlesonre...

#ChemSky #Metallopeptides #BioconjugateChem (5/5)

Cytotoxicity tests revealed that these Cu(II) cyclopeptides outperform cisplatin in some cancer cell lines, with lower IC50 values and high efficacy.

#ChemSky #Metallopeptides #BioconjugateChem (4/5)

Using ICP-MS, we confirmed that these metallopeptides significantly increase intracellular Cu(II) levels.

Meanwhile, fluorescence assays showed a strong induction of ROS, supporting an oxidative stress-driven cytotoxic mechanism.

#ChemSky #Metallopeptides #BioconjugateChem (3/5)

In this study, we designed and synthesized novel Cu(II) metallopeptides that efficiently generate ROS inside cells, leading to high cytotoxic activity.

#ChemSky #Metallopeptides #BioconjugateChem (2/5)

Exciting news! Our paper “Copper(II) Cyclopeptides with High ROS-Mediated Cytotoxicity” is now published in Bioconjugate Chemistry! 🎉

🔗 Read it here (50 free downloads):
pubs.acs.org/articlesonre...

Thanks to @pubs.acs.org for publishing our work

#ChemSky #Metallopeptides #BioconjugateChem (1/5)

Hello bsky! My lab at CiQUS develops metallopeptide tools for nucleic acid junctions and G-quadruplexes. We are particularly interested in peptide helicates and DNA-3WJ. Please follow us for more news about our research #DNA #RNA #metallopeptides #chemicalbiology #supramolecularchemistry