#Migrasome

THY1+ cancer stem cells drive metastasis through a pseudohypoxic state shaped by neutrophil-derived mitochondria - Nature Cell Biology Wan, Li, Cao and colleagues report a feedback crosstalk between THY1+ cancer stem cells and neutrophils via migrasome-mediated release of mitochondria, which induces a pseudohypoxic state and promotes...

☕Wan, Li, Cao et al report a feedback crosstalk between THY1+ #cancer #StemCells and neutrophils via #migrasome - mediated release of #mitochondria, which induces a pseudohypoxic state and promotes metastasis.
👉https://rdcu.be/e51HE
bit.ly/3ZZRw0q

Biogenesis of #Migrasome

"The calcium-binding ability of Synaptotagmin-1 is key to initiating migrasome formation", followed by Tetraspanin-mediated stabilization

#JCellBiol 2024
rupress.org/jcb/article/...