TIE2 links MEKK3–KLF2/4 and PI3K signaling in cerebral cavernous malformation Endothelial cell gain of MEKK3–KLF2/4 signaling confers CCM by increasing PI3K signaling. We show that the TIE2 receptor links MEKK3–KLF2/4 and PI3K signal

Extending our understanding of the #MolecularPathogenesis of #CerebralCavernousMalformations doi.org/10.1084/jem.... #CCM disease #DrugTarget #TranslationalScience

Osteoporosis: molecular pathogenesis and therapeutic interventions - Molecular Biomedicine Osteoporosis is a systemic skeletal disease. Genetic and environmental factors work together to cause increased bone resorption, decreased bone formation, bone remodeling imbalance, reduced bone mass,...

#Review
#Osteoporosis: molecular pathogenesis and therapeutic interventions doi.org/10.1186/s435...

#MolecularPathogenesis #TherapeuticIntervention #ResearchProgress