A non-canonical immunometabolic function of BRD3 during sepsis Wang et al. uncover a central role for BRD3 in driving harmful immune responses during sepsis. Blocking BRD3, either genetically or with the drug OTX015, protects mice from death. In patients, higher ...

#WeekendRead! #ImmunometabolismPower! #MoreThanItaconate! Wang, Tang, Kang &co show @cp-devcell.bsky.social that BRD3 induces ACOD1 via its kinase, rather than epigenetic, activity to potentiate inflammation during sepsis in a -partially- itaconate-independent manner!
www.cell.com/developmenta...