In older mice, where #MyogenicTone is weaker, #PrecapillarySphincters become even more critical barriers against #BloodPressure surges—compensating for #VascularStiffening and remodeling.

Postnatal development (day 3-19;2 mo;2 yr) of #ElasticLamina & #MyogenicTone in rat resistance arteries

#CircleOfWillis cerebral
2nd/3rd-order mesenteric

Transcripts of elastin and fibrillar collagens peak at D11~13

Michael Hill lab #FrontPharmacol 2023
www.frontiersin.org/articles/10....