Evaluating the practical aspects and performance of commercial single-cell RNA sequencing technologies. #SingleCell #scRNAseq #Benchmarking #NARgenomicsAndBioinformatics 🧪🧬 🖥️
academic.oup.com/nargab/artic...

MobiCT: a UMI-based circulating tumor DNA analysis pipeline. #UMIs #cfDNA #Nextflow #Bioinformatics #Genomics #NARgenomicsAndBioinformatics 🧪🧬 🖥️
academic.oup.com/nargab/artic...

MeTAline: enabling reproducible and scalable metagenomic analyses. #MetagenomicAnalysis #ShotgunMetagenomics #Snakemake #Containers #HPC #Bioinformatics #Genomics #NARgenomicsAndBioinformatics 🧪🧬 🖥️
academic.oup.com/nargab/artic...

Validate User

Excited to share that our article on accurate sample deconvolution of pooled snRNA-seq data using sex-dependent gene expression patterns is live on NAR Genomics and Bioinformatics! 🎉

Check it out here: doi.org/10.1093/narg...

#NARGenomicsandBioinformatics #snRNAseq #Genomics #Bioinformatics

GViNC: an innovative framework for genome graph comparison reveals hidden patterns in the genetic diversity of human populations. #GenomeGraphs #GraphsComparison #NARgenomicsAndBioinformatics
academic.oup.com/nargab/artic...

Cell-free DNA as a potential alternative to genomic DNA in genetic studies. #cfDNA #DNAseq #GeneticStudies #NARgenomicsAndBioinformatics
academic.oup.com/nargab/artic...

🌟 Discover NARGAB Editor's Choice articles, hand-picked by our Editor-in-Chief for their quality and impact.

👉 All articles are free to read and download, explore the full collection now!

🔗 academic.oup.com/nargab/pages...

#NARGenomicsandBioinformatics #EditorsChoice #OpenAccess

Explicit Scale Simulation for analysis of RNA-sequencing count data with ALDEx2. #RNAseq #Transcriptomics #Bioinformatics #NARgenomicsAndBioinformatics
academic.oup.com/nargab/artic...

An nf-core framework for the systematic comparison of alternative modeling tools: the multiple sequence alignment case study. #nfCore #ToolsComparison #MSA #NARgenomicsAndBioinformatics #Bioinformatics 🧬 🖥️
academic.oup.com/nargab/artic...

Targeted decontamination of sequencing data with CLEAN. #SequencingData #DataDecontamination #NARgenomicsAndBioinformatics #Bioinformatics #Genomics 🧬 🖥️
academic.oup.com/nargab/artic...

Advancing metagenomic classification with NABAS+: a novel alignment-based approach. #Metagenomics #Genomics #Bioinformatics #NARgenomicsAndBioinformatics
academic.oup.com/nargab/artic...

Comparison of single-cell long-read and short-read transcriptome sequencing via cDNA molecule matching: quality evaluation of the MAS-ISO-seq approach. #SingleCell #scRNAseq #ShortRead #LongRead #SequencingComparison #NARgenomicsAndBioinformatics
academic.oup.com/nargab/artic...

T2T-CHM13 versus hg38: accurate identification of immunoglobulin isotypes from scRNA-seq requires a genome reference matched for ancestry. #ReferenceGenomes #ImmunoglobulinIsotypes #scRNAseq #NARgenomicsANDBioinformatics #Bionformatics #Genomics 🧬 🖥️
academic.oup.com/nargab/artic...

Benchmarking of methods that identify alternative polyadenylation events in single-/multiple-polyadenylation site genes. #PolyA #MethodBenchmarking #Genomics #NARgenomicsAndBioinformatics
academic.oup.com/nargab/artic...

scHiGex: predicting single-cell gene expression based on single-cell Hi-C data Abstract. A novel biochemistry experiment named HiRES has been developed to capture both the chromosomal conformations and gene expression levels of indivi

scHiGex: predicting single-cell gene expression based on single-cell Hi-C data. #SingleCell #GeneExpression #HiC #NARGenomicsAndBioinformatics #Genomics 🧬 🖥️
academic.oup.com/nargab/artic...

Improved characterization of 3′ single-cell RNA-seq libraries with paired-end avidity sequencing Abstract. Prevailing poly(dT)-primed 3′ single-cell RNA-seq protocols generate barcoded cDNA fragments containing the reverse transcriptase priming site or

Improved characterization of 3′ single-cell RNA-seq libraries with paired-end avidity sequencing. #SingleCell #scRNAseq #AVITI #Genomics #Sequencing #Bioinformatics @elembio.bsky.social #NARgenomicsAndBioinformatics
academic.oup.com/nargab/artic...

IsopretGO—analysing and visualizing the functional consequences of differential splicing Abstract. Gene Ontology overrepresentation analysis (GO-ORA) is a standard approach towards characterizing salient functional characteristics of sets of di

IsopretGO—analysing and visualizing the functional consequences of differential splicing. #DifferentialSplicing #NARgenomicsAndBioinformatics 🧬 🖥️
academic.oup.com/nargab/artic...

Graphite: painting genomes using a colored de Bruijn graph Abstract. The recent growth of microbial sequence data allows comparisons at unprecedented scales, enabling the tracking of strains, mobile genetic element

Graphite: painting genomes using a colored de Bruijn graph. #MicrobialGenomes #GenomePainting #NARgenomicsAndBioinformatics
academic.oup.com/nargab/artic...

bcRflow: a Nextflow pipeline for characterizing B cell receptor repertoires from non-targeted transcriptomic data Abstract. B cells play a critical role in the adaptive recognition of foreign antigens through diverse receptor generation. While targeted immune sequencin

bcRflow: a Nextflow pipeline for characterizing B cell receptor repertoires from non-targeted transcriptomic data. #BcellReceptor #Nextflow #Bioinformatics #Genomics #NARgenomicsAndBioinformatics 🧬 🖥️
academic.oup.com/nargab/artic...