Classifying pediatric brain tumors by liquid biopsy using artificial intelligence See how M-PACT, an AI-powered algorithm can sift through ctDNA in cerebrospinal fluid and molecularly classify tumors based on their DNA methylation pattern

The Northcott group introduced M-PACT, a next-generation AI classifier using DNA methylation from liquid biopsies.
M-PACT overcomes challenges arising from low levels of DNA for accurate classification and monitoring of tumor microenvironment and evolution. #NatureCancer
tinyurl.com/36duu9az

Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity - Nature Cancer In this Review, Golebiewska and colleagues summarize the main features of the immunosuppressive microenvironment in glioblastoma (GBM) and discuss how different therapeutic approaches reshape GBM immu...

Can immunotherapy ever work in #glioblastoma?

In a new #NatureCancer review, we share our perspective on current limitations and future directions:
www.nature.com/articles/s43...

#NORLUX, #LIH , @fnr.lu #TELEVIE, @glioresolve.bsky.social, @michael-platten.bsky.social

CAR-adapted PIK3CD base editing enhances T cell anti-tumor potency - Nature Cancer By performing a CAR-adapted base-editing screen of phosphatidylinositol-3-kinase delta (PI3Kδ, PIK3CD), Bucher et al. identify mutations affecting endogenous PI3K–AKT signaling that enhances CAR T cel...

🚀New paper alert and a great way to start the year for Philip and #TeamJJ!🚀 Our paper on enhancing T cell anti-tumor potency through CAR-adapted PIK3CD base editing is now out in Nature Cancer. For more details visit: www.nature.com/articles/s43...

#TeamJJ #NatureCancer #iFIT #CARTcells

CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit Nature Cancer - Klebanoff and colleagues report that survival and persistence of CAR-T and CAR-NK cells are regulated by a FAS ligand–FAS autoregulatory circuit, showing that disabling FAS...

🚨Today, in #NatureCancer, we show that #CAR-T cells and #CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy. @mskcancercenter.bsky.social @parkerici.bsky.social

Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia - Nature Cancer Using multiple in vivo mouse models, Rehman and colleagues report that tumor-induced impairments in the muscle vasculature mediated by circulating activin A contribute to cachexia development during c...

New #NatureCancer paper: Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia. #Myoblue tinyurl.com/yhjx4sjt

An antibody–toxin conjugate targeting CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy - Nature Cancer Schrank et al. report the design and characterization of an antibody–toxin conjugate targeting CD47, promoting anti-tumor immunity in preclinical cancer models.

An antibody–toxin conjugate targeting the ‘don’t eat me’ signal CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy. #NatureCancer

www.nature.com/articles/s43...

We have two open positions for #computationalbiologists to work on:
1. Early cancer initiation following our work in #NatureCancer (Ref 5028)
2. Response to cancer immunotherapy following our work in #CancerCell (Ref 5073)
To apply use the provided reference numbers: www.qmul.ac.uk/jobs/vacanci...

The therapy led to the death of tumor cells at the treated sites and simultaneously activated the adaptive immune system to fight even distant metastases. The results published in the top journal #NatureCancer could improve the treatment of superficial tumors such as melanoma and breast cancer.

Multiple myeloma: Early detection of aggressive tumors Berlin researchers and their partners describe how aggressive variants of multiple myeloma can be detected early. Their comprehensive study in “Nature Cancer” shows how changes in genetic material aff...

Multiple #myeloma, a form of bone marrow cancer, can progress very aggressively. #mdcBerlin researchers now show for the first time at the #proteogenomic level how previously incurable forms can be recognized early and thus treated. 👇 #NatureCancer #ChariteBerlin #BIH