Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity - Nature Cancer In this Review, Golebiewska and colleagues summarize the main features of the immunosuppressive microenvironment in glioblastoma (GBM) and discuss how different therapeutic approaches reshape GBM immu...

Can immunotherapy ever work in #glioblastoma?

In a new #NatureCancer review, we share our perspective on current limitations and future directions:
www.nature.com/articles/s43...

#NORLUX, #LIH , @fnr.lu #TELEVIE, @glioresolve.bsky.social, @michael-platten.bsky.social

Happy to share a new #NORLUX study on how humanized patient-derived xenografts of #glioblastoma can be useful in investigating immunosuppression and clinically-relevant immunotherapy testing. See for more: www.biorxiv.org/content/10.1...
#immunotherapy, #preclinicalmodeling,

Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas Background: Precision medicine has transformed cancer treatment by tailoring therapies to specific molecular aberrations. Integrating high-resolution multi-omics with high-throughput functional profil...

Precision medicine in high-grade gliomas? Using high-throughput drug screen in #NORLUX patient-derived organoids multi-omics and machine learning, we assessed pharmacogenomics: www.biorxiv.org/content/10.1...
@fnr.lu, #precisionmedicine, #organoids, #drugscreen, #pharmacogenomics, #braintumors