Noncanonical Sirtuins FAM118B + FAM118A undergo filamentation & possess NADase activity 🤠

They are enriched in a special subnuclear domain & deplete cellular NAD+

A role in evolutionarily conserved innate immunity, like bacterial antiphage sirtuins

#NatureSMB 2025
www.nature.com/articles/s41...

Towards a molecular and structural definition of cell death Nature Structural & Molecular Biology - Cell death contributes to tissue homeostasis and plays critical roles in inflammation and host defense. Our increasing understanding of the physiological...

Cracking the #CellDeath code! What has the field recently discovered, and what is on the horizon? Delighted to contribute to this article in #NatureStructuralMolecularBiology!
#Immunology #NatureSMB #Inflammasomes
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