Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation The cytosolic LPS sensor caspase-4 controls antibacterial immunity by inducing pyroptosis and cytokine secretion. Began et al. show how remodeling of LPS membranes by interferon-induced GTPase GBP1 pr...

Studying #inflammasomes, caspase-4 & #pyroptosis? Learn how the binding affinities of #caspase-4 protein interaction with #lipopolysaccharide (micelles) was enabled by the in-solution measurement of a NanoTemper Technologies Monolith X spectral shift detection

Beyond excited that two of my brilliant students, Kirsten and Manasa, submitted their PhD theses in the last few weeks! Congratulations ladies! The future of science is in great hands. #inflammasomes #PhDone #ProudPI

Early weekend read: Our new review on #antiviral #inflammasomes spearheaded by Jennifer Wuerth with some recommendations for inflammasome detection is out!
@unibonn.bsky.social @immunosens.bsky.social

www.mdpi.com/1999-4915/18...

Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells - The EMBO Journal The innate immune system is known for its ability to recognize cytosolic DNA as evidence of infection, but detailed studies of this process have been mostly limited to mice and cell lines. To investig...

Ever wondered how you can specifically inhibit #AIM2 #inflammasomes? @y-m-tesfamariam.bsky.social generated inhibitory AIM2 #nanobodies to ‬dissect inflammasome responses to #poxvirus infections in human #PrimaryCells
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...

through inflammatory mechanisms, such as the activation of #inflammasomes. Under physiological conditions, microglia & astrocytes utilize distinct metabolic pathways, with the former utilizing #oxidativephosphorylation OXPHOS while astrocytes are predominantly glycolytic,

SpeckSeq enables high-throughput functional stratification of MEFV variants in autoinflammatory diseases. New study from Pauline Bronnec, Flora Magnotti, Thomas Henry @cinflammasome.bsky.social @ciri-lyon.bsky.social and colleagues: rupress.org/jem/article/...

#Autoinflammation #Inflammasomes

📝 Online now - the Review "Regulation of plant NLRs by post-translational modifications" from Yongliang Zhang and colleagues.

#PlantNLR #resistosomes #inflammasomes #InnateImmunity

Read it here 👉 authors.elsevier.com/a/1m9p%7E_M0...

Join us for an all-star line up for the 2026 #KeystoneSymposia on #InnateImmunity, co-organised by @jkagan1.bsky.social & @brozlab.bsky.social A joint meeting with joint meeting with the Keystone Aging Symposium in beautiful Banff, Canada. Register now! #inflammasomes, #TLRs, #myeloid, #epithelia

What do David Bowie, Queen & #inflammasomes have in common? Read our new review to find out! Deep dive into #NLRP1, #Inflammasomes, and innate immunity — covering activation, regulation & disease links. Great work from lab members Jeremy Yap & Kinga Duszyc!
authors.elsevier.com/a/1ly0C3vVUP...

Towards a molecular and structural definition of cell death Nature Structural & Molecular Biology - Cell death contributes to tissue homeostasis and plays critical roles in inflammation and host defense. Our increasing understanding of the physiological...

Cracking the #CellDeath code! What has the field recently discovered, and what is on the horizon? Delighted to contribute to this article in #NatureStructuralMolecularBiology!
#Immunology #NatureSMB #Inflammasomes
rdcu.be/eG1Nm

In 2009, Takeshi Ichinohe et al. of the @virusesimmunity.bsky.social lab demonstrated the requirement for ASC/caspase-1 #inflammasomes in the development of adaptive immune responses to respiratory influenza virus infection. rupress.org/jem/article/...

Day 2 of our International #Nanomedicine Conference. We kicked off with a great plenary from Kate Schroder showcasing her work on #inflammasomes. Followed by more fantastic talks. #drugdelivery #biosensors @mknanomedicine.bsky.social @kriskilian.bsky.social @yingzhu.bsky.social

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity | Journal of Experimental Medicine | Rockefeller University Press The inflammasome generates caspase-1 p20/p10, presumed to be the active protease. Boucher et al. demonstrate that the inflammasome contains an active caspa

We previously discovered that an unusual mechanism of feedback inhibition turns off #inflammasomes in cells (2018 J Exp Med; shorturl.at/hlFQS). Our new mouse model confirms this also terminates #inflammasomes in vivo (🧵2/3)
shorturl.at/HxS9a

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...

Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3)
shorturl.at/8lWxW

Exciting Day 3 RACI #MCCB2025 ! Starting with showstopping stories from GateBioscience's Pat Sharp on the development of Sec61 #inhibitors for Prion disease, & Prof. Avril Robertson from UQ on targeting NLRP3 #inflammasomes. Impressive preclinical efficacy fromin both stories!

Human proximal tubular epithelial cell interleukin-1 receptor signalling triggers G2/M arrest and cellular senescence during hypoxic kidney injury - Cell Death & Disease Cell Death & Disease - Human proximal tubular epithelial cell interleukin-1 receptor signalling triggers G2/M arrest and cellular senescence during hypoxic kidney injury

Well here it is folks - one of the last experiments from my #PhDThesis has been published. This one was a huge joint effort from the whole CIML Kidney Research Group! This part tells the second part of the story about how #inflammasomes can drive #chronickidneydisease
www.nature.com/articles/s41...

Now online - research briefing from @inflammasomelab.bsky.social Mercedes Monteleone on our recent @natimmunol.bsky.social publication on how pyroptotic cell corpses signal to dendritic cells from beyond the grave! #inflammasomes #pyroptosis #CellDeath #CLEC9A
Link: rdcu.be/d30EL

The question: intracellular #microbes potently induce #inflammasomes & #pyroptosis. How does a DC sense that a cell died under 'suspicious circumstances', & needs its corpse antigens sampled? More broadly, how do #inflammasomes enable the transition to #AdaptiveImmunity? (2/13)

First post here is about how excited i am that our review infographic on #inflammasomes in Hidradenitis suppurativa has made the cover of November’s BJD!

academic.oup.com/bjd/issue/19...

Looking forward to interacting with colleagues from #immunology #dermatology and #anatomy on this platform!

Hello! The Autoinflammatory Alliance has joined Blue sky. #autoinglammatory #immunedysregulation #cytokines #inflammasomes #rheumatology #immunology

Inflammasomes in neurological disorders — mechanisms and therapeutic potential - Nature Reviews Neurology Increasing evidence suggests that inflammasome activation contributes to disease progression in a wide variety of neurological conditions. In this Review, Ravichandran and Heneka discuss current under...

Recap #Inflammasomes in #neurologicaldisorders — mechanisms and therapeutic potential

www.nature.com/articles/s41...

#MedSky 🧪 #IDSky #ImmunoSky #Inflammasomes are multi-protein complexes that assemble within the cytoplasm of mammalian cells in response to pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs),

Mohamed Lamkanfi de l'Universiteit Gent a reçu le Prix quinquennaux des Sciences médicales des mains du Ministre de la Santé belge Frank Vandenbroucke pour ses travaux sur les #Inflammasomes youtu.be/AUviAF5XTqU