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Thanks for being aboard to #NephJC Flight ✈️
Final call for applications is near ⏳
Fasten your seatbelt… and don’t miss your chance to apply 😉
Until next time @NephJC this was your nephron @dramiliflores.bsky.social ✍️
www.nephjc.com/news/nephjc-...
#TenPostNephJC #NephTwitter #NephSky
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👉 So… is it time to trash hydralazine #NephJC? 🗑️
#TenPostNephJC #NephSky #medsky
➡️ Up next (05/06/26): TRPC6 inhibition in FSGS, a phase 2 trial of BI 764198
pubmed.ncbi.nlm.nih.gov/41616795/
Join us www.nephjc.com
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Want more info #NephJC #NephTwitter #NephSky
link to the NephJC blog @nephroseeker.medsky.social @dramiliflores.bsky.social
link to VAs @divyaa24
www.nephjc.com/news/hydrala...
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8/10
Does this study close the gap?
👉 If risk is not increased, does this support hydralazine use?
👉 Why does this debate persist, when in many settings hydralazine use is unnecessary? Why-dralazine?
#TenPostNephJC #NephJC #NephSky #MedSky
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7/10
Not significant results when accounting for competing risk of death
👉 Would this change your prescribing?
👉 Do you trust ICD-coded vasculitis?
#NephJC #TenPostNephJC #NephSky #MedSky
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6/10
Give me something clever to say about additional analyses, by Eric Weinhandl #NephJC
#TenPostNephJC #NephSky #MedSky
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5/10
A figure paints🖼️ a 1000 words!
Cumulative incidence curves show early separation, but overall risk remains low.
👉 Absolute difference is small
👉 Curves stay close over time
What do you think? #TenPostNephJC #NephJC #NephSky #MedSky
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4/10
1 post results 📊
💊 Hydralazine was associated with higher
vasculitis risk ➡️ 0.8%
🆚 ACEi/ARB ➡️ 0.5%
🧮 Absolute risk difference: +0.3%; HR 1.19 (95% CI 1.04–1.37)
#TenPostNephJC #NephJC #NephSky #MedSky
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3/10
1 post methods
📍 Retrospective cohort at Ontario from 1/2008 - 12/2021, >66y
📍 🆕 hydralazine (40,748) vs 🆕 ACEi/ARB users (542,388)
📍Outcome: any new vasculitis diagnosis (ICD-10) using propensity score across 21 covariates
#TenPostNephJC #NephJC #NephSky #MedSky
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2/10
What’d I miss?
Hydralazine is used for resistant HTN & HF. It may drive autoimmunity: apoptosis of primed neutrophils, NET disruption, and loss of tolerance ➡️ immune complex–mediated injury 💥 Prescribing it? 🤔
#TenPostNephJC #NephJC #NephSky #MedSky
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Still ordering hydralazine? 🤔
Beyond case reports, this large cohort compares hydralazine vs ACEi/ARB to estimate real-world vasculitis risk, will this 📉 bias & clarify the answer
Read more 👇
pubmed.ncbi.nlm.nih....
#TenPostNephJC #NephJC
#NephSky #MedSky
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Hydralazine, a 1950s drug still used at the edges of modern care. Cheap? Available?
Signal of benefit… shadowed by decades of immune toxicity signals
15 min to #TenPostNephJC #NephJC #NephSky #MedSky
pubmed.ncbi.nlm.nih.gov/6786464/
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Hydralazine is most classically associated with which serologic pattern in ANCA vasculitis?
25 min #TenPostNephJC #Nephsky #MedSky #NephJC
A. High-titer PR3-ANCA
B. High-titer MPO-ANCA
C. ANCA− / anti-GBM+
D. anti-dsDNA antibodies
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Congrats, Dr. Liz Kiernan! Recipient of a #research grant thru AKF’s prestigious CSN Prgm, which funds early-career #nephrologists dedicated to improving the diagnosis, treatment, and outcomes for people living with CKD #kidney @uwdeptmedicine.bsky.social #nephsky
www.kidneyfund.org/article/amer...
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Editorial: Special Report
Nobel prize–winning Treg cells in autoimmune kidney diseases and transplantation
doi.org/10.1016/j.kint.2026.01.005
#OpenAccess #NephSky #MedSky #celltherapy #autoimmunity
@griffithperkins.bsky.social @adelaideuni.bsky.social @kuleuvenuniversity.bsky.social
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XYZ of Statistics
Techniques to predict survival outcomes in nephrology: basics and traditional methods
doi.org/10.1016/j.kint.2024.08.041
#MedSky #NephSky #transplantation #KTx @sydney.edu.au
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Reduced podocyte stiffness is a feature of proteinuric kidney disease
doi.org/10.1016/j.kint.2026.02.028
#MedSky #NephSky #kidneydisease #podocyte
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N-propargylglycine restores survival by preventing calcium oxalate stone formation, tubular injury, and kidney dysfunction in a lethal mouse model of primary hyperoxaluria type 2
doi.org/10.1016/j.kint.2026.02.024
#MedSky #NephSky #OpenAccess
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🔗 www.docwirenews.com/post/what-sp...
What does the approval of the first drug to treat #FSGS mean for clinicians and patients? Kirk Campbell, MD, president of the National Kidney Foundation, weighs in. #nephrology #nephsky #glomerulardisease @kidney.org
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🚨We've moved! Balzer Lab🧪is now in Kiel (UKSH/CAU)🌊
And we're hiring for ERC-funded projects:
1 #Postdoc, 2 #PhD positions (sc/spatial+organoids)
🔬Study how human kidneys adapt to organ loss!
💰Competitive salaries+full benefits
📅Apply by June 1, 2026 balzer-lab.org/news/we-are-...
#NephSky #MedSky
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I remember Hydr-ANCA coined by Dr Roger Rodby
#NephJC #Nephpearls #NephSky
Molecular Mechanism Behind Hydralazine-Induced ANCA Vasculitis (Article shared by @melhoenig.bsky.social)
👉 www.med.unc.edu/medicine/new...
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Following the publication of this study in JASN, there was an interesting correspondence (see Pabla et al JASN 2024 and authors reply Pyne et al JASN 2024). Pabla et al point out that the organic cation transporter 2 (OCT2, encoded by the SLC22A2 gene) is involved in the basolateral tubular uptake and subsequent secretion of creatinine. PPIs may inhibit OCT2 (Nies et al PLoS One 2011). So Pyne et al, in their reply, present some additional analyses that suggest that the effect of pantoprazole compared with placebo on rate of eGFR change was attenuated in patients who discontinued treatment before eGFR reassessment (−0.04 ml/min per 1.73 m2 per year, 95% CI, −0.26 to 0.17) compared with those who remained on treatment (−0.60 ml/min per 1.73 m2 per year, 95% CI, −0.85 to −0.34). This disparity could support a reversible effect of pantoprazole on eGFR, possibly due to inhibition of creatinine secretion, or reflect a dose-response or threshold exposure effect. The case for PPIs causing kidney churn becomes even more weaker. For a longer explanation, see Lonnie Pyne’s rounds here.
Do PPIs cause kidney damage?
Read an update at the bottom of our summary www.nephjc.com/news/compass...
#MedSky #NephSky #EMIMCC
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Finding the etiology of membranoproliferative glomerulonephritis
doi.org/10.1016/j.kint.2026.02.030
#NephSky #MedSky @mayoclinicpath.bsky.social
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Complement inhibitors and B cell–modifying agents for IgA nephropathy—a Kidney Disease: Improving Global Outcomes (KDIGO) commentary
doi.org/10.1016/j.kint.2026.03.003
#OpenAccess #MedSky #NephSky #KDIGO #IgAN
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📣Kidney International introduces new article type
Clinical Journey in Translational Medicine uses a case report format as a catalyst for discovery.
📝Details: doi.org/10.1016/j.kint.2026.04.004
👉Examples:
✨ doi.org/10.1016/j.kint.2026.01.034
✨ doi.org/10.1016/j.kint.2026.01.035
#NephSky #MedSky
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💸 Get the best price for SCM26 with NKF Professional Membership: Join now to unlock SCM savings and exclusive benefits
Learn More: 👉 www.kidney.org/spring-clini...
#Nephrology #KidneyCare #NKFClinicals #NephSky
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A double-blind, randomized, placebo-controlled, phase 2 trial examined the efficacy and safety of monlunabant in adults with diabetic kidney disease
doi.org/10.1016/j.kint.2026.02.023
#NephSky #MedSky #OpenAccess #ckd #dkd #diabetes
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🔗 www.docwirenews.com/post/overcom...
Semaglutide has strong renal benefits, but cost and clinical inertia pose a barrier to its use. Katherine Tuttle offered advice on how to overcome the challenges and get this valuable therapy to patients. #kidneydisease #CKD #nephrology #nephsky
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We’re grateful to all of the early research contributions of Tanabe Pharma Corporation who made this achievement possible.
Read the study here: ascpt.onlinelibrary.wiley.com/doi/full/10....
#Pharmacology #Innovation #Lorundrostat
#CardioSky #NephSky
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