New Technology Develops Simple Diagnosis Method for Dementia Through Blood Marker Detection A new methodology has emerged for detecting a key blood marker related to neurodegenerative diseases, paving the way for easier dementia diagnoses.

New Technology Develops Simple Diagnosis Method for Dementia Through Blood Marker Detection #Japan #Tokyo #dementia_detection #Neurofilament #DNA_Aptamer

NfL levels in blood increase with age. Left: Mammalian species were grouped as young, adult, or aged depending on their known life expectancies. Shown are individual data points (y-axis (NfL [pg ml−1] on a log10 scale) with the median (red) and 95% confidence interval. Note that the sex was not known for 17 animals and that it was not possible to assign the sex to 316 of the aged humans. Right: Relationship between age [years] and NfL [pg ml−1] across the five species. Scatter points represent individual data, colored lines indicate generalized additive model (GAM) fits for each species.

Blood levels of #neurofilament light chain (NfL) increase with age in humans & predict #mortality. @mathiasjucker.bsky.social &co show that NfL age-related levels are comparable across mice, cats, dogs & horses, & may serve as a cross-species biomarker for #aging @plosbiology.org 🧪 plos.io/46iNxiX

NfL levels in blood increase with age. Left: Mammalian species were grouped as young, adult, or aged depending on their known life expectancies. Shown are individual data points (y-axis (NfL [pg ml−1] on a log10 scale) with the median (red) and 95% confidence interval. Note that the sex was not known for 17 animals and that it was not possible to assign the sex to 316 of the aged humans. Right: Relationship between age [years] and NfL [pg ml−1] across the five species. Scatter points represent individual data, colored lines indicate generalized additive model (GAM) fits for each species.

Blood levels of #neurofilament light chain (NfL) increase with age in humans & predict #mortality. @mathiasjucker.bsky.social &co show that NfL age-related levels are comparable across mice, cats, dogs & horses, & may serve as a cross-species biomarker for #aging @plosbiology.org 🧪 plos.io/46iNxiX

NfL levels in blood increase with age. Left: Mammalian species were grouped as young, adult, or aged depending on their known life expectancies. Shown are individual data points (y-axis (NfL [pg ml−1] on a log10 scale) with the median (red) and 95% confidence interval. Note that the sex was not known for 17 animals and that it was not possible to assign the sex to 316 of the aged humans. Right: Relationship between age [years] and NfL [pg ml−1] across the five species. Scatter points represent individual data, colored lines indicate generalized additive model (GAM) fits for each species.

Blood levels of #neurofilament light chain (NfL) increase with age in humans & predict #mortality. @mathiasjucker.bsky.social &co show that NfL age-related levels are comparable across mice, cats, dogs & horses, & may serve as a cross-species biomarker for #aging @plosbiology.org 🧪 plos.io/46iNxiX

New comparative study reveals significant bias across Quanterix Simoa assay formats for neurological biomarkers NfL and GFAP, highlighting the need for data harmonization. doi.org/10.1016/j.ne...
#Biomarkers #Neurofilament #GFAP #Simoa #Neurology #AssayValidation

Editors Choice 🌟

#Boxing causes repeated mild #TBIs that trigger inflammation and raise #neurodegeneration risk. This study measured #mitochondrialDNA, #cytokines, and #neurofilament light to identify #biomarkers and improve training #safety.
👉 Read: zurl.co/gG9PW

Neurofilament light chain improves clinical prognostic models for Guillain-Barré syndrome Background Several prognostic models predict clinical outcomes in Guillain-Barré syndrome (GBS). Recently, neurofilament light chain (NfL) has emerged as a prognostic biomarker. We investigated the added prognostic value of NfL in serum (sNfL) and cerebrospinal fluid (cNfL) to models based on clinical factors predicting respiratory failure and inability to walk in GBS. Methods We included patients from a randomised placebo-controlled trial (second intravenous immunoglobulin dose in GBS). Serum was acquired at entry and week 1, 2, 4 and 12 and cerebrospinal fluid at entry. NfL levels were determined on a single molecule array. The additional prognostic value of NfL to the (modified) Erasmus GBS Outcome Score ((m)EGOS) and (modified) Erasmus GBS Respiratory Insufficiency Score was evaluated using logistic regression analyses. Results In total, 293 patients were included (74 (25%) mechanically ventilated, 38/275 (13%) unable to walk at 26 weeks). Higher sNfL at entry, week 1 and week 2 and cNfL at entry were associated with inability to walk at 4 and 26 weeks. Neither sNfL nor cNfL levels at entry were associated with respiratory failure. The EGOS and mEGOS improved after adding NfL (∆C-statistic range: 0.01–0.11), especially the models predicting outcome at 26 weeks. A new model predicting inability to walk at 26 weeks consisting of sNfL at entry, GBS disability score at entry and Medical Research Council sum score at week 2 performed best (C-statistic: 0.88 (95% CI 0.83 to 0.94)). Conclusions Addition of NfL may improve clinical prognostic models for the prediction of inability to walk, but not of respiratory failure. Trial registration number NTR2224/NL2107. Data are available upon reasonable request.

🧬 Your neurons scream before your lungs do—serum NfL predicts paralysis in GBS before breath gives out. Prognosis upgraded. Biology debugged. 🧠📉
#Neurofilament #GBS #BioSignalSniffing
jnnp.bmj.com/content...

A Two-For-One Health Special Following the American Heart Association's guidelines for a healthy heart reduces the risk of Alzheimer's as well as cardiovascular disease.

A Two-For-One Health Special
The American Heart Association's guidelines for a healthy heart reduce the biomarkers for Alzheimer's AND the risk of cardiovascular disease. They're not hard! bit.ly/3DUjy5Q #neurofilament @alzheimerssoc.bsky.social #Alzheimer #dementia #hearthealth #cardiovascular

Elevated Cerebrospinal Fluid Ubiquitin Carboxyl‐Terminal Hydrolase Isozyme L1 in Asymptomatic C9orf72 Hexanucleotide Repeat Expansion Carriers Objective To identify biochemical changes in individuals at higher risk of developing amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD) via C9orf72 hexanucleotide repeat expansion...

(1/3) Happy to share our new work assessing protein changes in CSF of 48 asymptomatic C9orf72 variant carriers at higher risk of #ALS and #FTD.

We find an elevation in levels of UCHL1 protein, even in the absence of elevation in #neurofilament (NFL).

onlinelibrary.wiley.com/doi/full/10....