Serum NfL levels are elevated in NPC1 and correlate with disease severity—supporting its use as a biomarker for monitoring progression and treatment response in clinical trials. bit.ly/4fyjY09 #GIMO #NiemannPickDisease #TypeC1 #Serum #NeurofilamentLight

Evidence that minocycline treatment confounds the interpretation of neurofilament as a biomarker Gentile et al. report that treatment with the drug minocycline may cause neurofilament light concentration to rise in CSF and blood. This effect appears me

#Medsky🧪 #Neurosky #pharmasky Changes in NfL are generally assumed to reflect changes in neuronal damage . #minocycline may increase #neurofilamentlight concentration in CSF and blood, potentially mediated by changes in clearance rather than release from tissue…

academic.oup.com/braincomms/a...