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This study reveals distinct phenotypes in terms of how human respond to looming threats and how this process is modulated by two neuropeptides (vasopressin, angiotensin II). The image illustrates the threat looming and analytical pipeline - transforming pupillary and behavioral data from threat looming (symbolized by the snake) into specific phenotypes. By applying a computational framework integrating FPCA, clustering, and Markov Chain Analysis, the authors identified unique profiles (e.g., Profile E1) that exhibit different patterns of vigilance and cognitive engagement. These profiles show a distinct modulation by vasopressin, angiotensin II blockade and placebo. Image credit: Mengfan Han.
Neuromodulatory pathways help to process #threat, but what roles do specific neuropeptides play? A study in humans explores the impacts of manipulating two #neuropeptide pathways on responses to #looming stimuli; implications for #trauma #anxiety related disorders @plosbiology.org 🧪 plos.io/4tVHAm4
This study reveals distinct phenotypes in terms of how human respond to looming threats and how this process is modulated by two neuropeptides (vasopressin, angiotensin II). The image illustrates the threat looming and analytical pipeline - transforming pupillary and behavioral data from threat looming (symbolized by the snake) into specific phenotypes. By applying a computational framework integrating FPCA, clustering, and Markov Chain Analysis, the authors identified unique profiles (e.g., Profile E1) that exhibit different patterns of vigilance and cognitive engagement. These profiles show a distinct modulation by vasopressin, angiotensin II blockade and placebo. Image credit: Mengfan Han.
Neuromodulatory pathways help to process #threat, but what roles do specific neuropeptides play? A study in humans explores the impacts of manipulating two #neuropeptide pathways on responses to #looming stimuli; implications for #trauma #anxiety related disorders @plosbiology.org 🧪 plos.io/4tVHAm4
This study reveals distinct phenotypes in terms of how human respond to looming threats and how this process is modulated by two neuropeptides (vasopressin, angiotensin II). The image illustrates the threat looming and analytical pipeline - transforming pupillary and behavioral data from threat looming (symbolized by the snake) into specific phenotypes. By applying a computational framework integrating FPCA, clustering, and Markov Chain Analysis, the authors identified unique profiles (e.g., Profile E1) that exhibit different patterns of vigilance and cognitive engagement. These profiles show a distinct modulation by vasopressin, angiotensin II blockade and placebo. Image credit: Mengfan Han.
Neuromodulatory pathways help to process #threat, but what roles do specific neuropeptides play? A study in humans explores the impacts of manipulating two #neuropeptide pathways on responses to #looming stimuli; implications for #trauma #anxiety related disorders @plosbiology.org 🧪 plos.io/4tVHAm4
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zurl.co/M7FHE
Dual interference with host #neuropeptide signaling allows #parasitoid wasp to hijack sugar metabolism of its moth host - involving the help of parasitoid’s symbiotic virus!
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
Ion‐transport peptide amidated (ITPa) #neuropeptide is one of the few #Drosophila neuropeptides whose receptor was unknown till now. This anti-diuretic peptide was discovered back in 1992.
"A key part of that switch is #neuropeptide Y..a signaling molecule that helps the #brain juggle competing needs. When hunger or fear takes priority, NPY acts on Y1 receptors in the parabrachial nucleus to dampen ongoing #pain signals.": buff.ly/Zoq37wf
via sciencedaily
#ChronicPain #MedSky
Coucher de soleil - INRAE, Gérard Paillard
⏲️ Nos rythmes quotidiens s’ajustent aux saisons grâce à une horloge interne.
☀️ Chez la drosophile, des chercheurs #INRAE ont découvert qu’un messager du #cerveau, le #neuropeptide PDF, agit comme un interrupteur pour adapter sommeil et activité aux jours d’été.
👉 www.inrae.fr/actualites/l...
Social-sexual experience remodels SIFa-SIFaR synapses in the brain and ventral nerve cord of Drosphila melanogaster. Conditions from left to right: group reared, single reared, and sexually experienced.
An organism's internal state & behavioral outcomes are shaped by experience. This study reveals a #neuropeptide relay pathway, neuronal & non-neuronal, which orchestrates #SynapticPlasticity & context-dependent shifts in #mating duration in male #Drosophila @plosbiology.org 🧪 plos.io/4n8aUSV
Social-sexual experience remodels SIFa-SIFaR synapses in the brain and ventral nerve cord of Drosphila melanogaster. Conditions from left to right: group reared, single reared, and sexually experienced.
An organism's internal state & behavioral outcomes are shaped by experience. This study reveals a #neuropeptide relay pathway, neuronal & non-neuronal, which orchestrates #SynapticPlasticity & context-dependent shifts in #mating duration in male #Drosophila @plosbiology.org 🧪 plos.io/4n8aUSV
Social-sexual experience remodels SIFa-SIFaR synapses in the brain and ventral nerve cord of Drosphila melanogaster. Conditions from left to right: group reared, single reared, and sexually experienced.
An organism's internal state & behavioral outcomes are shaped by experience. This study reveals a #neuropeptide relay pathway, neuronal & non-neuronal, which orchestrates #SynapticPlasticity & context-dependent shifts in #mating duration in male #Drosophila @plosbiology.org 🧪 plos.io/4n8aUSV
New review to read! The pharmacotherapeutic potential of #neuropeptide Y for chronic pain.
➡️ Chronic pain requires new therapeutic options.
➡️ Discovered by Victor Mutt, neuropeptide Y (NPY) is rapidly emerging as a master regulator of pain relief.
🔗 doi.org/10.1111/joim.20118
Choose DSIP 2mg online for Sound Sleep and Healthy Life
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#DeltaSleep-inducingPeptide
#Neuropeptide
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Entdecke die Kraft der Endorphine: Glückshormone, Schmerzmittel & Euphorie-Booster. Lerne ihre Wirkung, Entstehung & wie du sie natürlich freisetzt. neelixberlin.de/endorphine/
#endorphine #euphorie #enkephaline #neuropeptide #glückshormone #glück #gefühle #dopamin #hormone #neelixberlin #sucht
Prof Leon Mutesa ended his talk with a preview of ongoing and future work in which HPA axis exploration shows biological variations related to #BDNF, #cortisol and #neuropeptide functions
11/11
Expression of hlh-17 and hlh-32 reporter alleles. Overlay with the NeuroPAL (otIs669) transgene demonstrates hlh-17(syb6303) and hlh-32(syb6078) expression in the AUA, VB2, and DB2 neurons. Representative close-up views for reporter alleles are shown with 10 μm scale bar.
bHLH genes have diverse roles during the development of the nervous system; this functional study of five #Celegans bHLH genes shows that some of them can regulate #neuropeptide secretion & significantly expand lifespan when mutated 🧪 @plosbiology.org plos.io/3W7OQMs
Expression of hlh-17 and hlh-32 reporter alleles. Overlay with the NeuroPAL (otIs669) transgene demonstrates hlh-17(syb6303) and hlh-32(syb6078) expression in the AUA, VB2, and DB2 neurons. Representative close-up views for reporter alleles are shown with 10 μm scale bar.
bHLH genes have diverse roles during the development of the nervous system; this functional study of five #Celegans bHLH genes shows that some of them can regulate #neuropeptide secretion & significantly expand lifespan when mutated 🧪 @plosbiology.org plos.io/3W7OQMs
Expression of hlh-17 and hlh-32 reporter alleles. Overlay with the NeuroPAL (otIs669) transgene demonstrates hlh-17(syb6303) and hlh-32(syb6078) expression in the AUA, VB2, and DB2 neurons. Representative close-up views for reporter alleles are shown with 10 μm scale bar.
bHLH genes have diverse roles during the development of the nervous system; this functional study of five #Celegans bHLH genes shows that some of them can regulate #neuropeptide secretion & significantly expand lifespan when mutated 🧪 @plosbiology.org plos.io/3W7OQMs
"Substance P: From Pain to Cancer" is now in print!
We contributed a chapter on immunobiology and pharmacology of neuropeptide substance P!
www.sciencedirect.com/science/arti...
#immunology #neurology #neuropeptide #pharmacology #ChemSky
Reconstruction of peptidergic networks in the cnidarian Nematostella vectensis. (A) Transgenic labeling of neurons expressing an LWamide neuropeptide. (B-C) Ligand activation curves of a Nematostella RPamide (B) and FLRNamide (C) receptor activated by two different peptides with different dose-response relationships. (D) Bipartite neuropeptide-GPCR interaction networks for all known Nematostella peptidergic signaling pairs. (E) Cellular signaling networks between LRWamide-expressing cells and cells expressing one of four LRWamide receptors. Edges are colored by receptor type in the target cell.
We wrote a review with Rafa Yuste on "Non-synaptic encoding of behavior by neuropeptides".
You can read it here:
https://zenodo.org/records/13691702
#neuroscience #neuropeptide #science
LeiferLab shone at #SfN2023, all four attendees
Kevin Chen, @funconn-worm.bsky.social, Sandeep Kumar, & AndrewLeifer got the opportunity to talk about their work. Thanks to Society For Neuroscience for such a wonderful meeting! 🪱🧠🔬🧑🔬 #Neuroscience #FunctionalConnectome #Neuropeptide #TWISP
