Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans | Nature Neuroscience Optogenetics has transformed basic research on neural circuitry, led to diverse experimental insights into human brain function and dysfunction, and opened pathways for clinical translation based on new understanding of how specific cell types contribute to cognition and behavior. Many of these translational pathways do not rely on the direct application of optogenetics in humans, but rather develop and advance other treatment modalities by leveraging causal knowledge derived from optogenetic circuit neuroscience. However, a recent proof-of-principle study—showing that optogenetics applied directly to the human central nervous system can treat blindness—underscores not only the curative potential but also the need for careful ethical consideration in the extension of direct optogenetic intervention to other disorders. Here, we review relevant considerations—including the selection of clinical indications, identification of molecular and optical strategies for specificity, and navigatio

Optogenetics revolutionizes neuroscience: unlocks brain insights, enhances cognition therapies. #NeuroscienceRevolution PMID:41254285, Nat Neurosci 2025, @NatureNeuro @Stanford https://doi.org/10.1038/s41593-025-02097-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1126/science.adu0431 No description available

Neuronal gene under noncoding RNA control influences drug & stress behavior. Game-changer in neurobiology! 💥 #NeuroscienceRevolution PMID:39666820, Science 2024, @ScienceMagazine https://doi.org/10.1126/science.adu0431 #Medsky #Pharmsky #RNA 🧪

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Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system - Nature Neuroscience This Review provides insights for construction of molecular cell atlases and outlines key study design considerations. The authors emphasize the power of single-cell and single-nucleus genomics in…

Unlock single-cell & single-nucleus genomics for insights into the nervous system's cellular diversity and transitions. #NeuroscienceRevolution PMID:39627588, Nat Neurosci 2024, @NatureNeuro @stanfordpress.bsky.social