Microglial NLRP3-gasdermin D activation impairs blood-brain barrier integrity through interleukin-1β-independent neutrophil chemotaxis upon peripheral inflammation in mice - Nature Communications The biological mechanisms regulating blood-brain barrier integrity remain unclear. Here, the authors identify microglial NLRP3-gasdermin D signaling as a driver of blood-brain barrier disruption durin...

#WeekendRead! #InflammasomePower #NotOnlyIL1b! Yoon, Yu &co show @naturecomms.bsky.social that LPS activates the inflammasome in microglia which drives blood brain barrier disruption not via IL1 but recruiting neutrophils & activating metalloproteinases!
www.nature.com/articles/s41...