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#ASCO25

πŸ”₯ MATTERNHORN: adding #Durvalumab to FLOT GEJ/GC ADK resectable

πŸ—£οΈ Dr. Janjigian

βœ… DFS 67 vs 57% at 24m HR 0.71
βœ… mOS 76 vs 70% at 24m
βœ… pCR 19 vs 7%
90% PD-L1+

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#ASCO25

Drug development track πŸ”₯

IZA-BREN/BL-B01D1

πŸ’‰ EGFR-HER3 bispecific ADC (TOP I) #NSCLC
☣️ Hematological
☣️ 1 ILD G2, no deaths

βœ…ORR 45.6%
βœ… Exon 20ins: 85%, HERm: 61.5%
βœ… SCLC ORR 75%!

#OncoNexion25 @oncoalert.bsky.social
@myesmo.bsky.social @ascocancer.bsky.social
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