Tau filaments formed into their distinctive paired helical filaments in Alzheimer's disease

#ICYMI spearheaded by Sofia Lövestam, Michel Goedert & @sjorsscheres.bsky.social's groups have identified a combination of 12 residues in tau’s fuzzy coat which, when mutated, facilitates assembly of amyloid filaments.
Read more in AlzForum: www.alzforum.org/news/researc...
#LMBintheNews #PAD12

We have revised our preprint on #PAD12 tau.

We have included new data on obtaining 95+% pure #Alzheimers PHFs, and further data to support our mechanistic model how phosphorylation in tau's fuzzy coat facilitates its assembly into #amyloid filaments.

www.biorxiv.org/content/10.1...