Negative Impact of p21‐Activated Kinase 4‐Mediated AMP‐Activated Protein Kinase Inhibition on Sarcopenia in Mice and Humans PAK4 is overexpressed in muscle atrophy and negatively correlates with muscle mass and function in humans. Inhibiting PAK4 activates AMPK/PGC-1α-driven mitochondrial biogenesis by blocking AMPKα2-S4...

#Article in #MedComm
Negative Impact of p21-Activated Kinase 4-Mediated AMP-Activated Protein Kinase Inhibition on Sarcopenia in Mice and Humans doi.org/10.1002/mco2...

#AMPK #mitochondria #MuscleAtrophy #PAK4 #PROTAC

Traumatic heterotopic ossification (HO) is an abnormal bone formation after injury. A study explores how necroptotic macrophages and p21-activated kinase 4 (Pak4) influence this process, revealing potential therapeutic targets.👍
#bone #Pak4
@brjournal.bsky.social
www.nature.com/articles/s41...

The HighHigh group showed #dysfunctional immune infiltration and overexpression of #therapeutic #targets like #PAK4 at baseline. The LowLow group exhibited a #LuminalA phenotype by the end of treatment