For patients with myeloid/lymphoid #neoplasms with FGFR1 rearrangements, #pemigatinib led to high rates of complete clinical and cytogenetic responses in chronic-phase disease, at 96% and 88%, respectively, with encouraging activity in blast-phase disease: https://ow.ly/UKCT50XKhvX
#HemeSky #OncSky
The December issue is available now! Check out the link below to read articles on #isatuximab for R/R AL #amyloidosis, ATRA-ATO combination therapy for APL, #pemigatinib for myeloid & lymphoid #neoplasms with FGFR1 rearrangements, and more: https://ow.ly/fzzm50XARLQ
Pemigatinib (Pemazyre): Uses in Cancer, Side effects, Dosage, Expectation, and more
oncodaily.com/drugs/pemiga...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Pemigatinib #Pemazyre #FGFR
Compared to traditional chemo (ORR ~20%) or chemo + durvalumab (ORR ~27%), pemigatinib offers a precision-driven advantage for FGFR2-altered patients π―
#Onco404 #Cancer #Kanser #Cholangiocarcinoma #Kolanjiyokarsinom #Pemigatinib #PrecisionOncology #TargetedTherapy #ClinicalTrials #MedSky #OncSky
π Other FGF/FGFR alterations (cohort B), or no FGF/FGFR alterations (cohort C).
π Key Findings (Cohort A)
β
Median PFS was 7.0 months.
β
Median OS: 17.5 months (vs. ~11-13 months with the 1L chemo Β± immunotherapy).
#Onco404 #Cancer #Kanser #Cholangiocarcinoma #Pemigatinib #PrecisionOncology
The phase II FIGHT-202 trialβs final results reveal pemigatinib, a selective FGFR1-3 inhibitor, shows 37% ORR in patients with advanced/metastatic #CCA harboring #FGFR2 fusions/rearrangements (cohort A) π
@myesmo.bsky.social #esmoopen
#Onco404 #Cancer #Kanser #Cholangiocarcinoma #Pemigatinib
@US_FDA approves #Futibatinib for FGFR2+ Advanced #CCA. Itβs been a great 2 years for BTC survivors with addition of #durvalumab + gem/cis as well as #ivosidenib (IDH1) #infigratinib #pemigatinib (FGFR2 fusion) #dabrafenib #trametinib (BRAF V600E)
@ILCAnews @MacarullaTeresa
3 @US_FDA & EMA approved #CCA targeted rx #pemigatinib #ivosidenib #dabrafenib #trametinib Unfortunately #NGS which identifies targeted rx underutilized & often not reimbursed. #NGS endorsed by @myESMO for all #CCA #ILCA22 @CCA_Alliance @curecc