Nice to have included this week the 1st patient in the 1st randomized clinical trial that aims to evaluate #phagetherapy in patients with prosthetic joint infection #PJI called #PHAGODAIR I. In this bag, a seringue of placebo, or a seringue with millions of active #Phages?

Amazing to present @JNInfectiologie the #PhagoDAIR multicenter clinical trial (Pherecydes) in patients with S. aureus prosthetic joint infection requiring #DAIR & suppressive antibiotics and enroll the first patient @CrioacLyon @CHUdeLyon the same day!

clinicaltrials.gov/ct2/show/NCT05…

We report at @JNInfectiologie congress our experience @CrioacLyon @CHUdeLyon about #phagetherapy: (I) 40 patients treated; (II) PJI is a relevant indication leading to the #PhagoDAIR clinical trial; (IV) we also treat endocarditis and pneumonia; (V) we are sharing our experience!

Congratulations Johan! Hope that the #PhagoDAIR procedure implemented @CrioacLyon @CHUdeLyon will help to control this relapsing prosthetic joint infection!

x.com/johan_CNice/st…

Frontiers | Phage Therapy as Adjuvant to Conservative Surgery and Antibiotics to Salvage Patients With Relapsing S. aureus Prosthetic Knee Infection Objectives: To report the management of three consecutive patients with relapsing Staphylococcus aureus prosthetic knee infection (PKI) for whom explantation...

Our #PhagoDAIR paper just published @FrontiersIn: #PhageTherapy as Adjuvant to Conservative Surgery and Antibiotics to Salvage Patients With Relapsing S. aureus Prosthetic Knee Infection ➡️ A potential option to keep the function in patients with #PJI!

frontiersin.org/article/10.338…

Today, a 15th patient received @CHUdeLyon #phagetherapy for a complex prosthetic-joint infection requiring #PhagoDAIR and local #phage application within #DAChydrogel. Incredible @CrioacLyon team! hope to control now the infection, and go ahead with @FondationHCL & @CIRI_Lyon!

Salvage Debridement, Antibiotics and Implant Retention (“DAIR”) With Local Injection of a Selected Cocktail of Bacteriophages: Is It an Option for an Elderly Patient With Relapsing Staphylococcus aureus Prosthetic-Joint Infection? Abstract. Local injection of a bacteriophages mix during debridement, antibiotics and implant retention (“DAIR”) was performed to treat a relapsing Staphyl

Two years ago, we treated this first patient with our #PhagoDAIR procedure (#phage during salvage Debridement, Antibiotics and Implant Retention #DAIR) ➡️ an interesting approach to try to keep the function in patients with #prostheticjointinfection #PJI!

academic.oup.com/ofid/article/5…

Evaluation of the Activity of a Combination of Three Bacteriophages Alone or in Association with Antibiotics on Staphylococcus aureus Embedded in Biofilm or Internalized in Osteoblasts | Antimicrobial Agents and Chemotherapy Staphylococcus aureus is responsible for difficult-to-treat bone and joint infections (BJIs). This is related to its ability to form biofilm and to be internalized and persist inside osteoblasts. Recently, bacteriophage therapy has emerged as a promising ...

Les #bactérophages utilisés pour traiter par #PhagoDAIR les patients avec infection de prothèse articulaire @CrioacLyon @CHUdeLyon ont une forte activité 💪 contre #Staph aureus 👾 et sont synergiques avec les #antibiotiques pour déstructurer le #biofilm!

aac.asm.org/content/early/…

This week, a 14th patient received @CHUdeLyon a personalized cocktail of GMP #bacteriophages prepared by our Pharmacist G. Leboucher for a prosthetic knee infection treated by #PhagoDAIR, a home-made concept @CrioacLyon (#Phage+conservative surgery) ➡️ incredible teamwork!

Cette semaine, un 14ème patient a reçu @CHUdeLyon un cocktail de #bactériophages GMP préparé par notre pharmacien G. Leboucher pour une infection de #prothèse traitée par #PhagoDAIR, un concept maison @CrioacLyon (#Phage+chirurgie conservatrice)! un travail d'équipe incroyable!

La semaine dernière, j’ai présenté aux #JNI2019 nos 2 années d’expérience @CrioacLyon sur l’utilisation de #bactériophages GMP: de mon point de vue, l’infection de prothèse est une indication émergente ! Le concept de #PHAGODAIR est né !

Last week, I presented at the #JNI2019 congress our 2-year experience @CrioacLyon about the use of GMP-like #bacteriophages: #PJI is, to my opinion, an emergent indication for #bacteriophages that could be administrated during #DAIR procedure. The #PHAGODAIR concept is born!