Revisiting Acyclovir Dosing for Adult Viral Encephalitis Using a Full Bayesian LeiCNS PBPK Modeling Approach - Clinical Pharmacokinetics Background and Objective Acyclovir is a primary treatment for central nervous system (CNS) infections caused by herpes simplex virus (HSV) and varicella-zoster virus (VZV). However, patient outcomes r...

Very informative #Pk_Pd study from @Clinicalpharmacokinetics on #acyclovir dosing for #HSV/#VZV #encephalitis. Standard regimens (10 mg/kg TID) may be inadequate . Alternative strategies: increasing dosing (QID) or extending infusion durations.

#IDSky

link.springer.com/article/10.1...