Schematic of how Vangl2 regulates cellular organization in both local and distant compartments through a vinculin-dependent mechanism. Left: Wildtype. Right: Localized Vangl2 deletion. The deletion of Vangl2 in either the greater epithelial ridge (GER) or the organ of Corti results in defects in cellular organization, such as the misorientation of hair cells and GER cells. These defects occur in the local and distant compartments, the latter via a vinculin-dependent process termed “compartment coupling”.
#Morphogens cooperate to guide development of the #cochlea. This Primer explores a @plosbiology.org study showing how #PlanarCellPolarity of individual cells is integrated across distinct regional compartments to ensure proper organ #morphogenesis. Paper: plos.io/4nmD8IW Primer: plos.io/3IjPkLR
