#Microtubule #SkeletalMuscle

TUBB6, β6V tubulin
⏫in muscle regeneration/dystrophy/myositis

TUBB6 overexpression➡️WT FDB muscle
⏫tubulin detyrosination + total α-tubulin

shRNA Tubb6➡️mdx FDB muscle
normalize cortical microtubule

#MyoTwitter
#HumMolGenet 2019
academic.oup.com/hmg/article/...

Vangl2, #PlanarCellPolarity protein, in Kidney Morphogenesis

Vangl2 lp/lp🐭
👉⏬Ureteric Budding/#BranchingMorphogenesis e13.5
👉Lack bush border/epithelial microvilli in proximal tubule e18.5
👉Smaller Glomerular tufts; loss of capillary loops

#HumMolGenet 2010
academic.oup.com/hmg/article/...