graphical abstract showing the combination of techniques used to analyze the dynamics of a de novo enzyme.

Our latest work is out! We combined #NMR with #Crystallography, #MD, and #ProteinMPNN to analyze the conformational dynamics of a de novo enzyme and redesigned it! Great collaboration between
@cathleenzeymer.bsky.social and the @sattler-lab.bsky.social.

www.cell.com/structure/fu...

ProteinDJ logo

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign

This cool study by Adrian Bunzel and co-workers puts great effort into capitalising on tools #RosettaDesign, #ESMFold, and #ProteinMPNN with evolutionary information to develop AI.zymes.
www.biorxiv.org/content/10.1...

Alright #ProteinMPNN users, have you ever tried using this on a protein that always exists as a heterodimer to make a version of said protein that will express alone? I REALLY want to give this a try so that we don't have to keep making this complex.

Talking about #ProteinMPNN - seminar by @JustasDauparas today 3pm @ml4proteins