Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1

This study demonstrates that #Prox1 suppresses #Retinoblastoma (RB) #CellProliferation and #DrugResistance through regulation of #Notch1, positioning Prox1 as a promising therapeutic target in RB and opening new avenues for #TranslationalOncology. #medsky

Read: link.springer.com/article/10.1...

Researchers at @uniheidelberg.bsky.social discovered that #PROX1 can block #CellFate plasticity in #hepatocytes, preventing #LiverCancer in mice.

@aryankamal.bsky.social
@moritzmall.bsky.social

📃 @naturegenet.bsky.social - go.nature.com/3D9AYuR
🎤 - bit.ly/4k42YAG

Manipulating #PROX1 switched mouse liver tumors between #hepatocellularcarcinoma and #cholangiocarcinoma states, nearly doubling survival in both. This underscores a new principle: actively stopping unwanted plasticity is crucial to #prevent disease.