This study highlights mitochondrial dysfunction in Slc3a1 knockout male #Kidneys, driven by altered NAD⁺ uptake in #ProximalTubule, as a key mechanism underlying sex differences in #Cystinuria, revealing new therapeutic avenues. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

#Polyvinylpyrrolidone has many applications in pharmaceuticals, food, beverages and cosmetics. This research on possible acute effects of PVP on #renal function reports #diuretic and #natriuretic effects in rats, via reduced #proximaltubule transport.
doi.org/10.14814/phy...
#Physiology

NNMT promotes tubular senescence and fibrosis in chronic kidney disease Chronic kidney disease (CKD) is a major global health issue, projected to become the fifth leading cause of mortality by 2040. Renal tubular cell senescence is a key driver of kidney fibrosis, the fin...

Excited to share the preprint of the latest work showing that #NNMT is a promising target in the early stage of #CKD preserving tubular homeostasis and reducing cellular #senescence

www.biorxiv.org/content/10.1...

#kidneydisease #senescence #fibrosis #NNMT #proximaltubule