Investigating RNA dynamics from single molecule transcriptomes. #FullLengthRNA #LongReads #Sequencing #Genomics #Transcriptomics #Bioinformatics #RNAdynamics
@cp-trendsgenetics.bsky.social‬ 🧪 🧬 🖥️
www.cell.com/trends/genet...

Optimising in-cell NMR acquisition for nucleic acids - Journal of Biomolecular NMR Understanding the structure and function of nucleic acids in their native environment is crucial to structural biology and one focus of in-cell NMR spectroscopy. Many challenges hamper in-cell NMR in ...

Super cool #RNAdynamics have been discovered by NMR. Next, we want to observe these dynamics in their native environment with #in-cellNMR. Current limitations include low sensitivity. My colleagues help address this by measuring selective T1 to shorten acquisition time.
🔗 bit.ly/4doL8FD #scicommUU25

Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA - Nature Repression of a messenger RNA by a cognate microRNA depends not only on complementary base pairing, but also on the rearrangement of a single base pair, producing a conformation that fits be...

Here is a phenomenal example of why we care about #RNAdynamics. My group shows an excited state of a miRNA:mSirt1 complex is involved in downregulation of Sirt1, a tumour promoter. Identifying these excited states can help guide design of miRNA mimics to treat cancer.
🔗 bit.ly/4kcBKI4 #scicommUU25

RNA Dynamics by NMR Spectroscopy RNA is a flexible molecule: This is what makes it functional, but also difficult to study, especially when the goal is to access those dynamic, often low-populated and short-lived conformers. Here th...

One misconception about RNA is that it’s static. RNA is actually ✨dynamic✨ and exists as a ground state in exchange with higher energy excited states. These #RNAdynamics allow RNA to perform functions and can be studied at the atomic level using NMR. Read more here 👉 bit.ly/43kbBQ3 #scicommUU25

💥Exciting #Postdoc opportunity in my lab at @cruk-mi.bsky.social to study the role of #RNADynamics in cancer progression!

⏰Deadline: 07/05/25

Apply 👇
www.cruk.manchester.ac.uk/career/mi-24...

⏩ Please share this with your network.

#CancerResearch #RNADynamics #RNAmodification #CRUK #postdoc