The giant E3 ligase #RNF213 serves as a master regulator of B-cell biology while its deficiency impairs PIK3/PIP3-mediated AKT-mTOR signaling and #MitochondrialRemodeling to disrupt B-cell development and #HumoralImmunity.

#OpenAccess: doi.org/10.1038/s413...

#RNF213, an IFN-inducible #E3Ligase, regulates B-cell development by degrading #SPIB; its loss disrupts AKT-mTOR signaling and antibody responses, while SPIB deletion or #PIK3C3 inhibition restores function. #HumoralImmunity

#OpenAccess in #STTT: doi.org/10.1038/s413...

This little tweezer followed me since the first day of my PhD with Stefania Spano. After four brilliant years with the @fletcherlab.bsky.social, it’ll be coming with me to a new chapter! It’ll be weird not to be working on gentle giant #RNF213, but really cool stuff is brewing, so watch this space.

To bless the new app, here is an IF image of #RNF213, amongst many other things, forming beautifully shaped lipid droplets.