The giant E3 ligase #RNF213 serves as a master regulator of B-cell biology while its deficiency impairs PIK3/PIP3-mediated AKT-mTOR signaling and #MitochondrialRemodeling to disrupt B-cell development and #HumoralImmunity.

#OpenAccess: doi.org/10.1038/s413...

#RNF213, an IFN-inducible #E3Ligase, regulates B-cell development by degrading #SPIB; its loss disrupts AKT-mTOR signaling and antibody responses, while SPIB deletion or #PIK3C3 inhibition restores function. #HumoralImmunity

#OpenAccess in #STTT: doi.org/10.1038/s413...

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Higher adherence to MedDiet, especially olive oil intake, is linked to stronger post-vaccine anti-Spike IgG responses, even after accounting for prior infection.
Diet & metabolic health may shape vaccine effectiveness more than we thought.

#MediterraneanDiet #HumoralImmunity
lnkd.in/dwWCCe7w

Researchers develop a synthetic #ProteinCondensate #nanoadjuvant platform that boosts antigen cross-presentation, drives strong CTL and #HumoralImmunity, activates cGAS–STING signaling, and enables scalable, modular #CancerVaccine design.

#OpenAccess #STTT: doi.org/10.1038/s413...

#Medsky🧪 #IDsky #Immunosky #publichealth
#Humoralimmunity induced by XEC monovalent vaccines against #SARSCoV2 sub variants XEC, LP.8.1, NB.1.8.1, XFG & BA.3.2 . The investigations, incl the recent one8, suggest that all 4 of the JN.1 subvariants-based vaccines

This study reports that #mRNAvaccines encoding full or partial #ChikungunyaVirus structural proteins, mCV-1 & mCV-2, induced strong cellular & #HumoralImmunity and provided broad cross-lineage protection in mice & #RhesusMacaques. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

While it was previously thought that γδ T cells primarily trigger inflammatory responses & directly kill infected cells, their contribution to #humoralimmunity during natural infection & vaccination has been a neglected area of research.

Dietary supplementation of #ArachidonicAcid promotes #HumoralImmunity

By. S. Feng, E. Ma, X. Na, Z. Wang, L. Zhao, A. Zhao, G. Cheng & colleagues at Tsinghua University

➡️ doi.org/10.1038/s443...

Humoral Immune Response to Orientia tsutsugamushi Infection: Recent Research Findings and Future Studies This study reveals gaps in humoral immunity to Orientia tsutsugamushi, stressing the need to clarify B cell responses in scrub typhus infection.

This commentary highlights major gaps in understanding #HumoralImmunity to #OrientiaTsutsugamushi, the cause of #Scrubtyphus, emphasizing the need for mechanistic studies of #Bcell responses to define deficiencies in acute & long-term immunity.
#OpenAccess: zoonoses-journal.org/index.php/20...

Importantly, the findings have implications for multidose vaccination schedules, highlighting ipsilateral immunization as an optimal strategy to rapidly maximize #humoralimmunity on a population level during the early phases of an infectious disease outbreak.

Frontiers | Obesity-compromised immunity in post-COVID-19 condition: a critical control point of chronicity Post-COVID-19 condition is recognized as a multifactorial disorder, with persistent presence of viral antigens, discordant immunity, delayed viral clearance,...

Subsequently, obesity-associated inflammatory insults are predicted to disturb cellular and #humoralimmunity by triggering abnormal cell differentiation and lymphocyte exhaustion….

t.co/tbprYyNLGG

Frontiers | Role of canonical and noncanonical autophagy pathways in shaping the life journey of B cells Autophagy is a regulated intracellular catabolic process by which invading pathogens, damaged organelles, aggregated proteins, and other macromolecules are d...

#MdSky🧪#ImmunoSky Overview #autophagy roles on #Bcell development, maturation & Their capacity to generate long lasting #humoralimmunity against microbial pathogens enables #Bcells to protect the host against repeated infections, provides for vaccine efficacy
www.frontiersin.org/journals/imm...

Cf. This is HK.3 (= EG.5.1+S:L455F)

Transmissibility/fitness (Re): Molecular phylogenetic-epidemic dynamics modeling by @jampei2 and @chainorato showed that the Re of HK.3 is 1.12-fold greater than that of EG.5.1, suggesting that S:L455F can contribute to the increased fitness of HK.3. 3/

MedSky 🧪 IDSky #Viralimmunology #Immunology #CovidIsNotOver @systemsvirology #Maskup😷 #Getboosted EG.5.1 has a characteristic amino acid substitution in the spike protein (S), S:F456L, which contributes to its escape from #humoralimmunity.