RNA is key to the dark matter of the genome − scientists are sequencing it to illuminate human health and disease | The-14 Scientists are sequencing all human RNA to map the RNome, uncover hidden gene regulation, and unlock new treatments for cancer and disease.

RNA is key to the dark matter of the genome − scientists are sequencing it to illuminate human health and disease
#Science #RNA #Genetics #RNome #Genome #Epigenetic #MolecularBiology #Biotech #Epitranscriptome #Genomics #DiseasePrevention #STEM #DNA
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Members of the Human RNome Project Consortium celebrating the 20th anniversary of the MODOMICS database during the HPRC workshop at Goethe University Frankfurt am Main, August 5th, 2025. Prof. Janusz Bujnicki in the bottom row, sixth from the left. Fifth from the left Prof. Stefanie Kaiser (Goethe University, Germany), fifth from the right Prof. Vivian Cheung (Brown University, USA) – corresponding authors of the article in Genome Biology. Photo courtesy of the HPRC.

📢 Our scientists are among the initiators and participants of the Human RNome Project - a global initiative aimed at fully characterizing all human RNA molecules and their chemical modifications. 🧬

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#RNome #RNA

Unlocking the regulatory code of RNA: launching the Human RNome Project | Genome Biology | Full Text The human RNome, the complete set of RNA molecules in human cells, arises through complex processing and includes diverse molecular species. While research traditionally focuses on four canonical nucleotide residues, the RNome, encompassing over 180 distinct modifications across organisms, with at least 50 in humans, is increasingly recognized. These modifications play critical roles in regulating RNA structure, stability, and function, yet the rules linking their precise locations to biological outcomes remain poorly defined. The Human RNome Project aims to map all RNA modifications, build essential resources, and harness new technologies to transform RNA biology, therapeutic development, agriculture, and even data storage.

Unlocking the regulatory code of #RNA: launching the Human #RNome Project genomebiology.biomedcentral.com/articles/10....