A potential new approach for treating Rett syndrome This work lays the foundation and provides preclinical evidence for a therapeutic approach for Rett syndrome that increases MeCP2 and confers functional improvement.

#RettSyndrome is a neurodevelopmental condition more common in girls than boys, for which there is no treatment. But a new study by the Zoghbi lab et al shows a new path that may lead to therapies. @bcmhouston.bsky.social @bcmgenetics.bsky.social #SciTranslMed blogs.bcm.edu/2026/03/05/f...

AMPAR inhibition lowers S1P in human blood and improves murine autoimmune neuroinflammation by blocking T cell egress from lymph nodes A clinically available AMPAR antagonist inhibits T cell egress from lymph nodes and shows therapeutic effects in mouse models of multiple sclerosis.

Out now in #SciTranslMed! We show non-canonical activity of AMPA receptor signaling in T cells. Oral selective noncompetitive AMPA receptor blockade ameliorates neuroinflammation by preventing T cell egress from lymph nodes and therefore may be repurposed to treat inflammatory conditions such as MS.

#SciTranslMed Prior vaccination prevents overactivation of innate immune responses during COVID19 breakthrough infection www.science.org/doi/abs/10.1126/scitrans... How vaccination protect against severe disease www.nature.com.um.debiblio.com/articles/d41586-025-0032...

#SciTranslMed Prior vaccination prevents overactivation of innate immune responses during COVID19 breakthrough infection www.science.org/doi/abs/10.1126/scitrans... How vaccination protect against severe disease www.nature.com.um.debiblio.com/articles/d41586-025-0032...

Lipidomic profiling of mouse brain and human neuron cultures reveals a role for Mboat7 in mTOR-dependent neuronal migration A monogenic form of autism due to MBOAT7 loss leads to a toxic accumulation of lipids and disrupted neural migration, corrected by mTOR inhibition.

Lipidomic profiling of mouse brain and human neuron cultures reveals a role for Mboat7 in mTOR-dependent neuronal migration #SciTranslMed #MassSpec www.science.org/doi/10.1126/...