USP1 deubiquitinates PARP1 to regulate its trapping and PARylation activity USP1 targeting improves PARP inhibitors effectiveness in ovarian cancer by regulating PARP1 trapping and catalytic activity.

Happy to share on Bluesky as my first post our new study on #chemoresistance in #ovarian-cancer just published in #Science_Advances. We show that #USP1 binds and regulates the activity of #PARP1 and that their combined inhibition sinergistically kills cancer cells.👇
www.science.org/doi/10.1126/...