KSQ‐4279, an Inhibitor of Ubiquitin Specific Peptidase 1, Enhanced the Chemotherapeutic Efficacy in ABCB1/ABCG2/ABCC1‐Mediated Multidrug Resistant Cancers KSQ-4279, an USP1 inhibitor in clinical trial, widely reversed multidrug resistance in refractory cancers by competing for the drug-binding pockets of ABCB1/ABCG2/ABCC1 and blocking chemotherapeutic ...

#Article in #MedComm
KSQ-4279, an Inhibitor of Ubiquitin Specific Peptidase 1, Enhanced the Chemotherapeutic Efficacy in ABCB1/ABCG2/ABCC1-Mediated Multidrug Resistant Cancers doi.org/10.1002/mco2...

#MultidrugResistance #MDR #USP1 #ABC #KSQ4279 #CombinationChemotherapy

USP1 deubiquitinates PARP1 to regulate its trapping and PARylation activity USP1 targeting improves PARP inhibitors effectiveness in ovarian cancer by regulating PARP1 trapping and catalytic activity.

Happy to share on Bluesky as my first post our new study on #chemoresistance in #ovarian-cancer just published in #Science_Advances. We show that #USP1 binds and regulates the activity of #PARP1 and that their combined inhibition sinergistically kills cancer cells.👇
www.science.org/doi/10.1126/...