Some cancer cells survive #radiation by relying on DNA repair proteins and sugar-driven metabolic pathways. In a recent study, Dr. Stephen Kron and colleagues have demonstrated that blocking #PARP1 and #OGT may make radiation more effective. Ludwig Cancer Research
https://ow.ly/SzLc50YuSvv

Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase #PARP1 #PARP2 #MECFS #LongCovid #HSV #NAD

bsky.app/profile/rene...

Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase Herpes simplex virus 1 infection triggers multiple changes in the metabolism of host cells, including a dramatic decrease in the levels of NAD+. In addition to its role as a cofactor in reduction-oxidation reactions, NAD+ is required for certain ...

Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase #PARP1 #PARP2 #MECFS #LongCovid #HSV #NAD

www.ncbi.nlm.nih.gov/pmc/articles...

New publication in collaboration with Magapor! The role of the PARP-1 in boar sperm and its relationship with sperm quality and fertility parameters. You can reach the published version at buff.ly/9Yw1Xfd and our preprint at buff.ly/h1oZjpw
#pig #AnimalReproduction #SpermChromatin #PARP1 #RAISE

Regulation of Alternative Splicing by PARP1 in HTR-8/Svneo Cells: Implications for Placental Development and Spontaneous Abortion

This study highlights the role of #PARP1 in regulating alternative #splicing in HTR-8/Svneo cells, reshaping #GeneExpression and functional traits of extravillous cytotrophoblasts, which are crucial for a successful pregnancy. #medsky

Read: link.springer.com/article/10.1...

Influence of PARP1 on CRISPR/Cas9 induced double strand break repair in proliferating cells. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.001

🔗 Influence of PARP1 on CRISPR/Cas9 induced double strand break repair in proliferating cells. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#CRISPR #GenomeEditing #Genomics #DNARepair #PARP1 #GeneticEngineering #MolecularBiology #GeneTherapy

New study from @uclamcdb.bsky.social shows MECP2 loss in #Rettsyndrome neurons triggers DNA damage & senescence via #PARP1 dysregulation. Restoring PARP1 reverses neuronal defects; potential therapeutic target https://ow.ly/guLJ50X4k2P

UCLA Broad Stem Cell Research Center | ISSCR

PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway - Scientific Reports Scientific Reports - PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway

#PARP1 #sustainability #health #publichealth

Excessively activated PARP-1
plays prominent roles in many diseases, such as
stroke, Parkinson’s disease, heart failure and diabetes.

PARP-1 increases
with increasing
cadmium (Cd) concentration
and prolonged exposure time
www.nature.com/articles/s41...

Current Advances in PARP1‐Targeted Theranostics Poly (ADP-ribose) polymerase 1 (PARP1) is crucial in DNA repair and is a key target for cancer and CNS disorder therapies, with PARP1 inhibitors showing success in treating cancers with BRCA mutation...

A review led by Yale Radiology looks at the current landscape of radiopharmaceuticals and radioligands targeting #PARP1 + discusses PARP1 tracers that can cross the blood-brain barrier. #theranostics
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

USP1 deubiquitinates PARP1 to regulate its trapping and PARylation activity USP1 targeting improves PARP inhibitors effectiveness in ovarian cancer by regulating PARP1 trapping and catalytic activity.

Happy to share on Bluesky as my first post our new study on #chemoresistance in #ovarian-cancer just published in #Science_Advances. We show that #USP1 binds and regulates the activity of #PARP1 and that their combined inhibition sinergistically kills cancer cells.👇
www.science.org/doi/10.1126/...