Let’s start with UTI 🦠 #infectiousdisease #medstudent #uti #antibiotics #medicine #internalmedicine #shorterisbetter
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#ShorterIsBetter
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#idsky #shorterisbetter outpatient oncology pts w/uncomplicated infections treated for 7d vs 14d for UTI, SSTI and LRTI showed no worse outcomes with shorter duration #idmeded #meded
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Good question for the next #UTI #guidelines or meanwhile for dedicated studies... Now the focus is on #ShorterIsBetter but the topic of modifying doses over the #antibiotic course in case of improvement according to primary infection site/source is still neglected.
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Several studies suggest that uncomplicated graft infections could be treated for 7 days.
Still, transplant patients have been excluded from most duration trials.
Time to bring them into the #ShorterIsBetter movement! 😉
🔓 www.sciencedirect.com/science/arti...
#IDSky #AMSsky #TxID
🧵(3/6)
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🦠 Shorter antibiotics (≤5 days) for respiratory infections match longer in effectiveness, to combat AMR, per our UK study of 640 patients @MDPIOpenAcces.
📢 Read: communities.springernature.com/posts/shorte...
🔗 Study: www.mdpi.com/1424-8247/17...
#AMR #AntimicrobialStewardship #ShorterIsBetter
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This metaanalysis of observational studies in SOT suggests that non-complicated graft infections could be treated 7d, and yet transplant patients have been excluded from most RCT on duration.
Time for a #ShorterIsBetter RCT in #TxID!
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... #IDsky #AMSsky
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Not a RCT, but more evidence for #Shorterisbetter in GAS pharyngitis. @bradspellberg.bsky.social
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In SHORTEN-2, immunocompromised hosts were not excluded if early clinical response and no unresolved source issues exist at randomization.
We hope to generate actionable data to guide the management of Pseudomonas BSI also in this population! 💪🏼
(🧵3/3) #AMSky #IDsky #TxID #IDOnc #ShorterIsBetter
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"If you're going to give antibiotics to people who don't need them, at least do us the courtesy of doing it for a brief period of time." 💊🦠 #ShorterIsBetter #AntimicrobialStewardship
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From @drtoddlee.bsky.social @dremilymcd.bsky.social @angelahuttner.bsky.social @josemolinagb.bsky.social et al in @jama.com Network Open:
Systematic review & Non-inferiority Meta-Analysis of 7 vs 14 days for GNR BSI
4 RCTs, 7 non-inf to 14
#IDSky #ShorterIsBetter
jamanetwork.com/journals/jam...
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Cannot thank @drandrekalil.bsky.social enough for inviting me to write this commentary on the BALANCE trial for ACP Journal Club in @annalsofim.bsky.social this month!
#ShorterIsBetter #IDSky @unmc-id.bsky.social
www.acpjournals.org/doi/10.7326/...
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#IDSky I updated all-in-one table for #ShorterIsBetter approach based on @bradspellberg.bsky.social original work. All references of mentioned studies in the table are available on: www.bradspellberg.com/shorter-is-b...
PDF document is availabe on demand (send me DM).
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#ShorterIsBetter… menos cuando hablamos de la 2ª temporada de Sensible & Resistente, que ojalá no terminara 😜
¡Imposible resistirse a estos anfitriones! Gracias a @listeriacolectiva.bsky.social y @micromunidad.bsky.social por llevar una manera tan amena de aprender a nuestros auriculares 🎧 😉
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This highlights the importance of the analytical method to reduce risk of bias when measuring abx benefits and harms in observational studies. This also supports the fact that there is no additional harm to using shorter courses and are still consistent with #shorterisbetter.
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Only 58 patients to go!
Recruitment is moving along as planned, and fingers crossed, we’ll be done before summer.
Huge shoutout to the @shorten2trial.bsky.social team for keeping up the great work!
#AMSsky #IDSky #ShorterIsBetter
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Now that the master of #ShorterIsBetter is here, is there any reason to stay on Twitter? Welcome @bradspellberg.bsky.social !!
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Instant follow my dear friend
Welcome to #idsky
@bradspellberg.bsky.social
Wouldn't imagine #idsky without him, his knowledge and wisdom
He's the myths buster
#shorterisbetter
A legend & jedi master for #IDTwitter and everyone #mustfollow him #medsky #AMSsky #utisky #tbsky
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#shorterisbetter is prevailing even in immunocompromised/transplant infectious diseases
Thank you Dr.Brad Spellberg, for everything you're doing in ID #idsky #medsky #AMSsky
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5-7 days for SSSI coz source controlled. #ShorterIsBetter
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With our @shorten2trial.bsky.social RCT we will hopefully provide further specific data on P. aeruginosa BSIs, including those occurring in immunocompromised hosts 🤞🏻
#ShorterIsBetter #PsWatch #AMSsky #IDSky #IDOnc #TxID
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‼ Excepciones a #Shorterisbetter 👉🏻 Hay situaciones concretas en las que un ciclo "corto" de antibióticos NO es igual de eficaz que uno "largo" (ej. otitis media < 2 años, aspergilosis pulmonar crónica...)
Tabla noviembre 2024 #BradSpellberg
#EAAD #WAAW #AntimicrobialResistance
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🫁💊 #Shorterisbetter Pauta "corta" vs "larga" en tuberculosis (noviembre 2024)
#EAAD #WAAW #AntimicrobialResistance #KeepAntibioticsWorking
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🦠💊Acabamos la #WAAW2024 con la versión actualizada de la tabla #Shorterisbetter de Brad Spellberg (nov 2024)
¡Recuerda! Una pauta "corta" antibióticos es IGUAL de eficaz que "larga"(en gran nº situaciones) y:
⬇️resistencias, efectos adversos, costes
⬆️adherencia
www.bradspellberg.com/shorter-is-b...
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Shorter is better table is updated
Wow, 4 RCTs [non S.aureus] bactremia
7d is non inferior to 14d
Spread the word
Credit goes to my friend: Dr.Brad Spellberg #shorterisbetter #idsky #medsky #tbsky
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Shorter is better table is updated
Wow, 4 RCTs [non S.aureus] bactremia
7d is non inferior to 14d
Spread the word
Credit goes to my friend: Dr.Brad Spellberg #shorterisbetter #idsky ##medsky #tbsky
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Wow, 4 RCTs [non S.aureus] bacteremia
7= 14
Spread the word #shorterisbetter #idsky
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🔥Everyone's favorite #shorterisbetter table is updated🔥
"BALANCE is now published,
so the table is now updated!
GNB bacteremia is now listed as Bacteremia(non S.aureus)
Neary 5,000 patients have now been randomized to 1 vs. 2 Constantine Units for non S. aureus bacteremia " Dr.Spellberg #idsky
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Very proud of our team for recruiting over 100 patients to the BALANCE study just published in NEJM
7 versus 14 days of antibiotics for blood stream infections
@muhc
#shorterisbetter
#IDsky
#MEDsky
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