Seeing the extended fam at Thanksgiving used to be awkward enough. Now add to that having to explain why I became a shrinkee as they look down at my tiny naked body on the dining room table 😳. *Sigh* at least it's only for a couple days.
#shrinkingman #shrinksky #shrinkingfetish
Trying to network with more psychiatrists. (I know we are here on Bluesky!)
#Skychiatry
#psychiatry
#Psychsky
#Medsky
#Shrinks
#Shrinksky
#MentalHealth
#psychology
![L-methylfolate (5-methyltetrahydrofolate or 5-MTHF) is a bioactive form of folate that is often used in supplements. The relationship between folate and cancer risk is complex and influenced by various factors, including genetic polymorphisms and the form of folate consumed.
Several studies have investigated the impact of folate and its metabolites on cancer risk. For instance, a nested case-control study found that serum levels of 5-MTHF were generally associated with a reduced risk of cancer, except in individuals with the MTHFR C677T (TT) polymorphism, where higher levels of 5-MTHF were associated with an increased cancer risk.[1] This suggests that genetic factors can modulate the effect of folate on cancer risk.
Another study indicated that high levels of folate from supplements and fortification were not associated with an increased risk of colorectal cancer.[2] Additionally, a meta-analysis of randomized controlled trials found no significant effect of folic acid supplementation on total cancer incidence, colorectal cancer, prostate cancer, lung cancer, breast cancer, or hematological malignancy.[3]
However, it is important to note that excessive folate intake, particularly in the form of synthetic folic acid, has been associated with potential cancer-promoting effects in some contexts, such as in individuals with certain genetic predispositions or pre-existing neoplastic conditions.[4-5]
In summary, L-methylfolate does not generally increase the risk of cancer, but its effects can vary depending on genetic factors and the specific cancer type. It is crucial to consider individual patient factors and genetic predispositions when evaluating the risk associated with folate supplementation.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:axowp52lzh2thepp6knswttb/bafkreifzbkghh6gp76gjs6u7ovrq2t6sqt5j3vqqvekxdrist7io7qy7im)
L-methylfolate (5-methyltetrahydrofolate or 5-MTHF) is a bioactive form of folate that is often used in supplements. The relationship between folate and cancer risk is complex and influenced by various factors, including genetic polymorphisms and the form of folate consumed. Several studies have investigated the impact of folate and its metabolites on cancer risk. For instance, a nested case-control study found that serum levels of 5-MTHF were generally associated with a reduced risk of cancer, except in individuals with the MTHFR C677T (TT) polymorphism, where higher levels of 5-MTHF were associated with an increased cancer risk.[1] This suggests that genetic factors can modulate the effect of folate on cancer risk. Another study indicated that high levels of folate from supplements and fortification were not associated with an increased risk of colorectal cancer.[2] Additionally, a meta-analysis of randomized controlled trials found no significant effect of folic acid supplementation on total cancer incidence, colorectal cancer, prostate cancer, lung cancer, breast cancer, or hematological malignancy.[3] However, it is important to note that excessive folate intake, particularly in the form of synthetic folic acid, has been associated with potential cancer-promoting effects in some contexts, such as in individuals with certain genetic predispositions or pre-existing neoplastic conditions.[4-5] In summary, L-methylfolate does not generally increase the risk of cancer, but its effects can vary depending on genetic factors and the specific cancer type. It is crucial to consider individual patient factors and genetic predispositions when evaluating the risk associated with folate supplementation.
#PsychSky #ShrinkSky #Skytriatry #MedSky
Was the current consensus on whether l-methylfolate increase cancer risk. Attached is what OpenEvidence came up with. Is the issue of C677T a) solid (e.g., clear increase in cancer risk in that setting) and b) due to less uptake into brain and more
#PsychSky #ShrinkSky #Psychskyatry etc see below (for the both of us!
Trying to connect to more shrinks:
#Skychiatry
#psychiatry
#Psychsky
#Medsky
#Shrinks
#Shrinksky
#MentalHealth
#psychology
"Even if you halt me at one millimeter, I can live to grow another day. Better than being the first man to shake hands with an e-coli."
Sam gives me a sad smile and gets right to work. I do whatever I can to assist, while I still have the inches.
#sizesky #shrinksky #shrinkingman #tinyman #miniman
