Sirtuins = cellular longevity switches 🧬

These NAD+-dependent proteins:
✅ Repair DNA damage
✅ Boost mitochondrial health
✅ Regulate metabolism
✅ Enhance stress resistance

The challenge? Moving from mouse models to validated human therapeutics.

#Longevity #AgingScience #Sirtuins

Anam Naseer, Pranoy Toppo, Mahmood Akbar, Aamir Nazir investigate the mechanistic aspect of mitochondrial #sirtuins in modulating age-associated #neurodegeneration, specifically #ParkinsonsDisease, using #Celegans

Read doi.org/10.1242/dmm....

Enhancing NAD+ Efficiency by Energizing Sirtuins Researchers publishing in Physical Review X have discovered compounds that can double the efficiency of the sirtuin SIRT3 in processing NAD+. Looking for a new way to boost enzymes The […]

Researchers are exploring ways to directly enhance sirtuin activity without relying on a substrate-based approach. Success could open new doors to combat multiple aspects of aging and improve healthspan.

www.lifespan.io/news/enhanci...
By: Josh Conway

#longevity #health #NAD #Sirtuins

Harvard Researchers Explore Human Genes Potential to Reverse Aging. Sirtuins are a family of proteins that have been identified as a critical factor in the regulation of aging and disease. Article Here www.artbookvideo.com/post/harvard...

#aging #senior #health #sirtuins #DNA @klab.bsky.social

Revealing chromatin-specific functions of histone deacylases Histone deacylases are erasers of Nε-acyl-lysine post-translational modifications and have been targeted for decades for the treatment of cancer, neurodegeneration and other disorders. Due to their r...

Histone deacylases (#HDACs and #sirtuins) have specific and quite different ways of finding their targets through #chromatin 🧬.
Why do we know this, and what are we doing to study it in detail? All the info in our new review with @beatfierz.bsky.social! 👇🏻
portlandpress.com/biochemsoctr...