Electrospun thermoplastic polyurethane/nano-Ag-coated clear aligners for the inhibition of Streptococcus mutans and oral biofilm

An #electrospun #ThermoplasticPolyurethane aligner coating with 2 wt% #AgNPs shows strong #antibacterial action against #Streptococcusmutans, reducing #biofilm while preserving mechanics and #biocompatibility to lower #Cariesrisk.
Nanotechnology Reviews: doi.org/10.1515/ntre...

Antimicrobial Effects of Cannabidiol (CBD)-infused Lozenges against Streptococcus mutans in Oral Health A recent clinical trial has unveiled the potential of CBD-infused lozenges in combating harmful bacteria linked to tooth decay. Researchers explored the effects of CBD on Streptococcus mutans, a key player in cavity formation. Over 15 days, participants in the experimental group consumed one 300 mg CBD lozenge daily, allowing it to dissolve for gradual absorption. The results? A significant reduction in bacterial levels compared to the control group. This promising finding highlights CBD’s antimicrobial properties and its potential role in improving oral health. This study opens doors to innovative CBD-based therapies for dental care, an exciting step forward in oral hygiene science. - https://freedomwares.ca/antimicrobial-properties-of-cbd-lozenges/?fbclid=IwY2xjawJSyfFleHRuA2FlbQIxMAABHfxtrmxTwSO_cXVYvS3ONw_tdSjCsDgZKRO327_ycfYnC53piuTFaTqt-w_aem_ZDzZhvjACXDxAzYc32JGig #Cannabidiol(#CBD) #OralHealth #DentalCare #StreptococcusMutans #Antimicrobial #CBDLozenges #DentalResearch #HealthyMouth #CBDHealth

Antimicrobial Effects of CBD-infused Lozenges against Streptococcus mutans in Oral Health

This study opens doors to innovative CBD-based therapies for dental care, an exciting step forward in oral hygiene science.
- tinyurl.com/4wchdt2s

#CBD #DentalCare #StreptococcusMutans #Antimicrobial

mucG, mucH, and mucI Modulate Production of Mutanocyclin and Reutericyclins in Streptococcus mutans B04Sm5 | Journal of Bacteriology S. mutans must be able to outcompete neighboring organisms in its ecological niche in order to cause dental caries. S. mutans B04Sm5 inhibited the growth of neighboring commensal streptococci through production of reutericyclins via the muc biosynthetic ...

New publication is out!@JBacteriology @JCVenterInst @UCSDMedSchool #streptococcus #streptococcusmutans #microbiology #Genomics #dentistry #pangenomics
Genome completed and transcriptomics using @nanopore
Pangenomics analysis using #anvio

journals.asm.org/doi/10.1128/jb…

Coming very soon:
#microbiology #dentistry #biochemistry #streptococcusmutans

Analysis of the Streptococcus mutans Proteome during Acid and Oxidative Stress Reveals Modules of Protein Coexpression and an Expanded Role for the TreR Transcriptional Regulator | mSystems Dental caries is the most common chronic infectious disease worldwide and disproportionately affects marginalized socioeconomic groups. Streptococcus mutans is considered a primary etiological agent of caries, with its pathogenicity being dependent on ...

New manuscript is out! Proteomics of Streptococcus mutans during acid and oxidative stresses:@mSystemsJ @JCVenterInst @UCSDMedSchool @StJudeResearch @UNCPharmacy @UR_Med #Microbiology #dentistry #proteomics #streptococcusmutans

journals.asm.org/doi/10.1128/ms…

Coming very, very soon!
#streptococcusmutans
#dentistry
#microbiology

mucG, mucH, and mucI modulate production of mutanocyclin and reutericyclins in Streptococcus mutans B04Sm5 Streptococcus mutans is considered a primary etiologic agent of dental caries, which is the most common chronic infectious disease worldwide. S. mutans B04Sm5 was recently shown to produce reutericyclins and mutanocyclin through the muc biosynthetic gene cluster, and to utilize reutericyclins to inhibit the growth of neighboring commensal Streptococci. In this study, examination of S. mutans and muc phylogeny suggested evolution of an ancestral S. mutans muc into three lineages within one S. mutans clade, and then horizontal transfer of muc to other S. mutans clades. The roles of the mucG and mucH transcriptional regulators, and the mucI transporter, were also examined. mucH was demonstrated to encode a transcriptional activator of muc. mucH deletion reduced production of mutanocyclin and reutericyclins, and eliminated the impaired growth and inhibition of neighboring Streptococci phenotypes which are associated with reutericyclin production. Δ mucG had increased mutanocyclin and reutericyclin production, which impaired growth and increased the ability to inhibit neighboring Streptococci. However, deletion of mucG also caused reduced expression of mucD, mucE , and mucI . Deletion of mucI reduced mutanocyclin and reutericylin production, but enhanced growth, suggesting that mucI may not transport reutericyclin as its homolog does in Limosilactobacillus reuteri . Further research is needed to determine the roles of mucG and mucI , and to identify any co-factors affecting the activity of the mucG and mucH regulators. Overall, this study provided pangenome and phylogenetic analysis that serves as a resource for S. mutans research, and began elucidation of the regulation of reutericyclins and mutanocyclin production in S. mutans . Importance S. mutans must be able to outcompete neighboring organisms in its ecological niche in order to cause dental caries. S. mutans B04Sm5 inhibited the growth of neighboring commensal Streptococci through production of reutericyclins via the muc biosynthetic gene cluster. In this study, carriage of muc was examined across S. mutans , which showed that 35 of 244 RefSeq S. mutans genomes encoded muc and provided a valuable update to the S. mutans pangenome and phylogeny. The roles of the mucG and mucH transcriptional regulators, and the mucI transporter, were also examined. All 3 genes impacted production of mutanocyclin and reutericyclins, which affected the growth rates, transcriptomes, and the ability of the S. mutans strains to inhibit the growth of neighboring commensals.

New preprint is live! A major update to the Streptococcus mutans pangenome and phylogeny, as well as elucidation of the roles of the mucG and mucH regulators, present in 35 strains.

#streptococcusmutans
#microbiology
#dentistry

biorxiv.org/content/10.110…

Frontiers | Tetramic Acids Mutanocyclin and Reutericyclin A, Produced by Streptococcus mutans Strain B04Sm5 Modulate the Ecology of an in vitro Oral Biofilm The human oral microbiome consists of diverse microbes actively communicating and interacting through a variety of biochemical mechanisms. Dental caries is a...

New publication!
#microbiology
#dentistry
#streptococcusmutans
@FrontOralHealth

frontiersin.org/articles/10.33…