...assess the strength of presented data based on analysis of the figures. E.g. if I was a reviewer for this paper, I would look at this fig and dismiss the paper out of hand, because the maps are nonsense. This is an extreme example, but similar principles apply to analysis of most #structbio data.

Podcast CHEmic #63 – Aby se vědecký ústav dostal na špičku, musí dát šanci mladým talentům Moderní technologie a brilantní adepti vědecké dráhy jsou nejlepší investicí výzkumných ústavů. Že se na tom nevyplatí šetřit, říká v podcastu CHEmic zástupkyně ředitele ÚOCHB Pavlína M. Řezáčová.

🎙 Moderní technologie a brilantní adepti vědecké dráhy jsou nejlepší investicí výzkumných ústavů.

Že se na tom nevyplatí šetřit, říká v #podcastCHEmic zástupkyně ředitele Pavlína M. Řezáčová.

#podcast #chemic #chemie #iocb #uochb #iocbprague #akademievedcr #cryoem #mikroskopie #structbio

When I arrived to NYC as a postdoc, NYSBDG was my first local meeting, and I was blown way by the world-class quality of the science.

It's a great opportunity to meet the local #structbio & #cryoem community, and it's coming up in two weeks, so register now at the eventbrite link below!

The external speakers are set and ready to navigate the intersection of #AI & #StructBio for the Bridging Atoms and Algorithms: A Symposium on AI and Structural Biology.
🗓️Tuesday & Wednesday, March 17–18, 2026
🏫Campus of Vanderbilt University
bit.ly/4ldBOaz

This is an excellent meeting for #structbio folks in the northeast & tristate area! Great lineup 🤩

The free and open and INGENIOUS format (which dates back to the 70’s) of the PDB file and associated analysis code for #structbio is completely under appreciated. PDB predates Genbank by a decade! People dedicated their working lives to overnight shifts at the synchrotron to collect these data.

Using Federal funding, we described for the first time, the architecture of the Pentameric subunits of the HIV capsid and how they differ in binding to the rest of the capsid which is important for nuclear entry and drug binding, and we show this structurally. #structbio #FundScience

Friendly reminder, a model does not have a resolution; a map has a resolution. A model has spatial variance, rotamers, populations, etc. The map has resolution(s), threshold, density falloff, any number of correlation coefficients, etc.
Please, do not assign a resolution to your model.
#structbio

Arg18 Substitutions Reveal the Capacity of the HIV-1 Capsid Protein for Non-Fullerene Assembly In the fullerene cone HIV-1 capsid, the central channels of the hexameric and pentameric capsomers each contain a ring of arginine (Arg18) residues that perform essential roles in capsid assembly and ...

And we're live! This was actually the first project I started in my PhD, a little over 3 years ago when I joined the Pornillos lab for #HIV #StructBio in February of 2021. Shifted focus to a more high profile project, but methods were developed specifically because this mutant was so weird! #cryoEM

Arg18 substitutions reveal the capacity of the HIV-1 capsid protein for non-fullerene assembly bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Second paper from my thesis work is live on biorxiv.

Allosteric regulation of quaternary structure in the HIV capsid. Mutational analysis of a binding site may have long range effects on a protein even if the tertiary structure is seemingly unchanged, but seeing is believing. #structbio #cryoEM

Protein structure prediction has reached the single-structure frontier - Nature Methods Dramatic advances in protein structure prediction have sparked debate as to whether the problem of predicting structure from sequence is solved or not. Here, I argue that AlphaFold2 and its peers are ...

Good/Quick Read
"Distributions of conformations are the future of structural biology"
Actually they are the contemporary of #structbio. When @sjorsscheres.bsky.social released ReLION 1.13 way back in idk 2014, model free ab initio refinement and 3D classification were part of the standard protocol

#StructBio
🧪

#UCSFchimera website is down for maintenance
remember there's a PDF guide posted and its pretty much never down. this is legacy chimera (the OG!)
🧪 #biophys #structbio
www.cgl.ucsf.edu/chimera/pdf/...