1️⃣ 𝘛𝘩𝘦 𝘤𝘰𝘯𝘵𝘦𝘹𝘵
In mammals, the Y-chromosome gene Sry triggers testis development, while its absence leads to ovary formation. Although this is well known, scientists continue to ask how epigenetic regulation and 3D genome organisation control this process

#CNAG #StructuralGenomics #SexDetermination

The E. histolytica endoribonuclease L-PSP has a prototypical YjgF/YER057c/UK114 family structure with a large allosteric site that can be targeted for rational drug-discovery efforts #StructuralGenomics #EndoribonucleaseLPSP #EntamoebaHistolytica doi.org/10.1107/S205...

Two structures of Legionella pneumophila serogroup 1 peptide deformylase (PDF) provide insight into PDF inhibition and support continued anti-PDF drug-development efforts #SSGCID #StructuralGenomics #>PeptideDeformylases doi.org/10.1107/S205...

Apo and dUMP-bound structures of Legionella pneumophila dUTPase revealed a potential new binding site and active-site structural differences when compared with human dUTPase #SSGCID #StructuralGenomics doi.org/10.1107/S205...

Differences in the binding pocket provide insight for the development of selective inhibitors that target bacterial TrpRS without interfering with the human cytosolic form #StructuralGenomics #NeisseriaGonorrhoeae #TryptophanylTRNASynthetase doi.org/10.1107/S205...

Two structures of Brucella ovis leucine-, isoleucine-, valine-, threonine- and alanine-binding protein are reported that show its conformational flexibility in the absence of bound amino acids
#SSGCID #StructuralGenomics #Brucellosis t.co/aDI9PPMCdu

Three crystal structures of two NAD(P)H nitroreductases from Klebsiella pneumoniae are presented and an analysis of their structures and their flavin mononucleotide-binding mode is provided. #Nitroreductase #SSGCID #StructuralGenomics t.co/0dFO1nRWzB