Towards a Better Control of Engineered Circuit Transcription in Bacterial Genomes The transcription of genes and engineered circuits can deeply vary when inserted into different genomic loci. This unpredictable performance, termed context sensitivity, complicates strain development...

👍Congrats to L. Janniere, N. Sarica and B. Jester from #Synovance. Their model is suggesting that DNA looping is an important cause of context sensitivity and can be used for better controlling the transcription of engineered circuits. #syntheticbiology #AppliedMicrobiology

www.mdpi.com/3171930