The Effect of Early Tumor Necrosis Factor Inhibitor Initiation on Chronic Opioid Use in Individuals with Axial Spondylarthritis Objective Opioid use remains common despite effective therapies for axial spondyloarthritis (axSpA). We assessed whether early tumor necrosis factor inhibitor (TNFi) use is associated with reduced r...

6️⃣ The big picture
Early TNFi ≠ less opioid use.
Future work should include pain scores, disease activity, and social factors to fully understand pain and opioid trajectories in axSpA.

#Rheumatology #axSpA #Opioids #TNFi #Pharmacoepidemiology

#TNF #psoriasis #TNFi #geriatrics #publichealth #iatrogenic #hematology #immunology #health

Increased risk of lymphoma with infliximab: aHR = 2.49

Increased risk of leukemia with etanercept: aHR = 3.87

Increased risk of leukemia with adalimumab: aHR = 3.36
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www.nature.com/articles/s41...