Welsh firm Antiverse raises funds for AI antibody platform Cardiff's Antiverse has raised $9.3m to develop its AI-based design platform for antibodies against hard-to-reach targets like GPCRs and ion channels.

#Antiverse #AI #AIantibodyplatform #biotech #drugdiscoveryprogrammes #antibodybasedtherapeutics #antibodies #drugtargets #Gproteincoupledreceptors #GPCR #ionchannels #NxeraPharma #GPCRs #cellularcommunication #transmembraneprotein #Tcellreceptor #TCR #antiPD1antibodies #drugdiscovery
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Antigen affinity modulates ERK pulsing frequency during T cell activation Real-time, single-cell imaging reveals ERK signaling dynamics in response to T cell receptor stimulation.

www.science.org/doi/10.1126/...
T cells achieve precise antigen discrimination by relying on the temporal stability of #Tcellreceptor (TCR) interactions with antigens. Given that time is central to antigen discrimination,

#Medsky🧪#Immunosky New "TCR rules" dictate how a #Tcellreceptor (TCR) drives the differentiation of naive #Tcells into peripheral Tregs within the gut. In contrast to the traditional emphasis on environmental factors,

The canine T cell receptor repertoire AbstractBackground. Tseek is a method of sequencing T cell receptor (TCR) repertoires with minimal bias. This work aimed to develop methods to characterize

Excited to share WALTHAM’s paper in ImmunoHorizons. With Girihlet & Mars Advanced Research Institute, we characterised canine TCR repertoires. We revealed individual, breed & age-associated signatures, enabling immune monitoring, disease detection & intervention assessment. #TCellReceptor

Single-cell sequencing of full-length transcripts and T-cell receptors with automated high-throughput Smart-seq3 - BMC Genomics We developed an automated high-throughput Smart-seq3 (HT Smart-seq3) workflow that integrates best practices and an optimized protocol to enhance efficiency, scalability, and method reproducibility.…

Single-cell sequencing of full-length transcripts and T-cell receptors with automated high-throughput Smart-seq3. #SingleCell #FullLengthRNA #TcellReceptor #Transcriptomics 🧬 🖥️