Inhibiting LDHA to prevent Ascending #AorticAneurysm #AorticRupture
🐭BAPN -/+ Oxamate or FX11

Protein/histone lactylation mainly in Mo/Mφ &👤 #ThroacicAorticDissection

Mo/Mφ with high lactylation gene score➡️Angptl4 signals to EC/SMC/fibroblast

#CellSignal 2025
www.sciencedirect.com/science/arti...

⏬Mechanosensing & ⏫inflammation of aortic #EndothelialCell as a potential disease driver in #MarfanSyndrome 😎

A novel Marfan🐭➡️early #ThroacicAorticDissection #AorticRupture Fbn1G234D/G234D T50=5 wk

⏬pSMAD2 ↔️pERK1/2

#AortaEd
Hiromi Yanagisawa lab #CircRes 2025
www.ahajournals.org/doi/suppl/10...

Male predominance in sporadic #ThroacicAorticDissection suggests contributions from X-linked genes
RTL9
ZNF182/275/81

Discovery cohort: 364 cases
Replication cohort: #MillionVeteranProgram 516 cases
+ARIC 753 cases

#AortaEd

Am J Med Genet A 2024
onlinelibrary.wiley.com/doi/10.1002/...