How does a tick-borne virus invade our brain? A groundbreaking study reveals the key receptor LRP8 and designs a "molecular decoy" therapy that showed near-complete protection in mice.
doi.org/10.1016/j.xi...
#tickborneencephalitisvirus #virology

#Flavivirus #BloodBrainBarrier

Bulk RNAseq 👤🧠microvascular #EndothelialCell + viral protein E Domain III (cell attachment factor) of #TickBorneEncephalitisVirus vs #WestNileVirus

Convergent pathways TLR2 TAM IFN JAK/STAT Vesicle-mediated transport

#SciRep 2022
www.nature.com/articles/s41...